ISRCTN92093279
已完成
未知
Simvastatin and severe Sepsis: a randomised controlled Trial
Oxford Radcliffe Hospitals NHS Trust (UK)0 个研究点目标入组 104 人2005年9月1日
概览
- 阶段
- 未知
- 干预措施
- 未指定
- 疾病 / 适应症
- Severe sepsis
- 发起方
- Oxford Radcliffe Hospitals NHS Trust (UK)
- 入组人数
- 104
- 状态
- 已完成
- 最后更新
- 8年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •Patients eligible for inclusion:
- •1\. Those admitted to the Adult Intensive Care Unit at John Radcliffe Hospital, Royal Sussex County Hospital and the Royal Berkshire Hospital (last two centres added 10/10/2007\)
- •2\. Severe sepsis or develop severe sepsis whilst in intensive care
- •Patients must be randomised and receive the first dose of simvastatin within 24 hours of first organ dysfunction to be included in the study.
排除标准
- •Patients will be excluded from the trial if they:
- •1\. Are receiving simvastatin or another statin prior to admission
- •2\. Refuse consent or their relatives refuse assent
- •3\. Are less than 16 years of age
- •4\. Are included in another interventional study
- •5\. Have a known adverse reaction to statins
- •6\. Have an indication or contraindication to treatment with a statin, according to the treating physician
- •7\. Are unable to receive enteral medications
- •8\. Are receiving drugs known to interact with simvastatin
- •9\. Have active liver disease
结局指标
主要结局
未指定
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