Assessment of the simvastatin effect on the outcome of patients with brain injuries in IC

Phase 2

• Conditions: brain injuries.; Traumatic cerebral oedema, Diffuse brain injury,Focal brain injury,Epidural haemorrhage, Traumatic subdural haemorrhage, Traumatic subarachnoid haemorrhage, Intracranial injury with prolonged coma, Other intracranial injuries, Intracranial injury, unspec; S06.1, S06

• Registration Number: IRCT201305075363N3
• Lead Sponsor: Vice- Chancellor for Research of Zanjan University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

APACHEE score less than 35, age between 18 and 60 years old, patients with brain injuries that scheduled to ICU admission
Exclusion criteria:Receiving NSAIDS or corticosteroids, known hypersensitivity to the study drugs, history of cardiac, respiratory, neuromuscular, hepatic or renal diseases, history of brain injuries and pregnancy.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
CRP. Timepoint: first day , 72 h after brain injury. Method of measurement: Kit.;IL6. Timepoint: first day , 72 h after brain injury. Method of measurement: ELISA Kit.;The number of admission days in the ICU. Timepoint: The last day of admission in the ICU. Method of measurement: Observation.;Patient GCS at the first day of admission in the ICU. Timepoint: The first day of admission. Method of measurement: Physical examination.;Patient GCS at discharge from the ICU. Timepoint: The last day of admission. Method of measurement: Physical examination.;Time of connecting the patient to the ventilator. Timepoint: Time in which the patient is connected to the ventilator. Method of measurement: observation.