NT-proBNP as a Tool for the Detection of Acute Pulmonary Artery Embolism (APE)

Completed

• Conditions: Pulmonary Embolism; Pulmonary Embolism Without Mention of Acute Cor Pulmonale

• Registration Number: NCT01633671
• Lead Sponsor: University of Ulm

Brief Summary

In patients with suspected APE (Acute Pulmonary Embolism) referred to the intensive care unit (ICU)after major surgery, serum NT-proBNP (N-terminal proBNP), Troponin-I and D-dimers were measured according to the standard hospital protocol. To definitively confirm or exclude APE, all patients underwent an angiographic CT-scan of the thorax.

Detailed Description

In patients with suspected APE referred to the intensive care unit after major surgery, serum NT-proBNP, Troponin-I and D-dimers were measured according to the standard hospital protocol. Blood samples were obtained within one hour after the onset of clinical symptoms.

Definitive confirmation or exclusion of APE was performed with an angiographic CT-scan of the thorax.

Study Timeline

• Study Start: 2008-11
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Study First Submitted: 2012-06-28
• Study First Submitted QC: 2012-06-29
• Status Verified: 2012-07
• Study First Posted: 2012-07-04
• Last Update Submitted: 2012-07-04
• Last Update Posted: 2012-07-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

all patients referred to the ICU with suspected APE

Exclusion Criteria

none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute pulmonary embolism: CT-proof yes vs. no	1 hour after onset of clinical symptoms

Trial Locations

Locations (1)

University of Ulm, Michelsberg anaesthesiologic ICU; 🇩🇪 Ulm, Baden-Wuerttemberg, Germany