The Diagnostic Value of APTT/Fibrinogen Ratio in Pulmonary Embolism

Recruiting

• Conditions: Acute Pulmonary Embolism
• Interventions: Diagnostic Test: 2018 edition of the Guidelines for Diagnosis

• Registration Number: NCT06192199
• Lead Sponsor: Nanfang Hospital, Southern Medical University

Brief Summary

From January 1, 2023 to December 30, 2023, patients who were suspected of pulmonary embolism and underwent CTPA examination at Nanyang Hospital of Southern Medical University were divided into pulmonary embolism group and non pulmonary embolism group. 1. Collect relevant data, including gender, age, primary disease, CTPA imaging and reports, BNP, troponin, electrocardiogram, cardiac ultrasound, PT, APTT, TT, fibrinogen, D-dimer, etc., and analyze demographic data, pulmonary embolism risk grading, APTT/fibrinogen ratio, and determine their cut-off values through statistical analysis of the two groups. 2. Follow up on the APTT/fibrinogen ratio after anticoagulation treatment and bleeding in the pulmonary embolism group.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-01
• Study First Submitted: 2023-12-14
• Study First Submitted QC: 2024-01-03
• Study First Posted: 2024-01-05
• Status Verified: 2025-01
• Last Update Submitted: 2025-04-13
• Last Update Posted: 2025-04-16
• Primary Completion: 2025-05-01
• Study Completion: 2026-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

1. Voluntary signing of informed consent form;
2. When signing the informed consent form, the age is equal to or greater than 18 years old, regardless of gender;
3. From January 1, 2023 to December 30, 2023, the patient was diagnosed with suspected pulmonary embolism at the Southern Hospital of Southern Medical University and underwent enhanced pulmonary artery scanning examination.

Exclusion Criteria

1. Patients with gastrointestinal bleeding, severe trauma, acute coronary syndrome, severe liver disease (childC grade), and coagulation dysfunction;
2. Patients with pulmonary embolism diagnosed outside the hospital and regular anticoagulation;
3. Patients undergoing regular anticoagulant therapy such as atrial fibrillation and valve replacement;
4. Patients deemed unsuitable for participation in this study by the researchers.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients without acute pulmonary embolism	2018 edition of the Guidelines for Diagnosis	-
Patients with acute pulmonary embolism	2018 edition of the Guidelines for Diagnosis	-

Primary Outcome Measures

Name	Time	Method
Cutoff value of APTT/FIB between patients with and without acute pulmonary embolism	2024.01-2026.12

Trial Locations

Locations (1)

Nanfang hospital of Southern Medical University; 🇨🇳 Guangzhou, Guangdong, China