A randomized double blind placebo parallel controlled study on the effect of decoction of Caulis Lonicerae on the plaque fiber cap thickness in patients with carotid atherosclerosis

Not Applicable

Recruiting

• Conditions: Carotid atherosclerosis

• Registration Number: ITMCTR2100004445
• Lead Sponsor: Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. The patients with carotid atherosclerotic plaques were diagnosed by color Doppler ultrasound;
2. hsCRP >= 2 mg/L;
3. Patients between 40 and 80 years old, regardless of gender;
4. Patients who can take medicine for a long time;
5. Patients who have informed consent and signed the informed consent.

Exclusion Criteria

1.Acute or subacute hemorrhage in plaque;
2.Plaque is calcified and fibrotic;
3.Can not do MRI(such as carrying a pacemakerdenturecardiac stent);
4.Patients with active ulcers and bleeding tendency who take anticoagulants (such as warfarin) for a long time; 5.Patients are using dual antiplatelet drugs;
6.Patients with serious arrhythmia, atrial fibrillation and heart failure;
7.Patients with severe liver, kidney, hematopoietic system, endocrine system, respiratory system, hypertension, infectious and non infectious inflammation, immune related and other primary diseases, whose liver function is more than 1.5 times higher than the upper limit of the normal value, and whose Cr is higher than the normal value;
8.Any other life-threatening or serious disease that cannot be treated for 12 months and thus affects the evaluation results;
9.Pregnant or lactating women, women with a recent pregnancy plan;
10.Patients with allergic constitution;
11.Other diseases or psychosis that may limit efficacy evaluation or patient follow-up in the opinion of researchers;
12.Patients who have participated in clinical trials of other drugs in the past 4 weeks.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Minimum fiber cap thickness;

Secondary Outcome Measures

Name	Time	Method
Volume percentage of bleeding in plaque;Volume of Fiber cap;Volume percentage of Fiber cap;Volume of bleeding in plaque;Vascular stenosis rate;Blood lipid;Volume percentage of plaque calcification;High-sensitivityC-reactive protein;Blood pressure;Maximum vascular wall thickness;Volume percentage of Lipid-Rich Necrotic Core;Average value of vascular wall thickness;Volume of Lipid-Rich Necrotic Core;Blood glucose;Volume of plaque calcification;Weight;Carotid Atherosclerosis Score;Total vessel wall load (volume of vascular wall/total volume of blood vessels);Volume of vascular wall;