Early Detection of Aortic Stenosis in the Community: Role of Clinical and Echocardiographic Screening During Influenza Vaccination Multi-center, Prospective, Observational Cohort Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Aortic Stenosis
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
- Enrollment
- 167
- Locations
- 2
- Primary Endpoint
- comparison of detection rate of aortic stenosis
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Prospective cohort study to test the hypothesis that patients identified with severe aortic stenosis are under-diagnosed and under-treated. Such patients shall be identified by auscultation or target echocardiography during flu vaccination. The hypothesis is that this will increase detection of aortic stenosis in the community.
Detailed Description
The design plans for two study phases: 1. Feasibility study: screening by auscultation and target echocardiography during flu vaccination in a single practice in Birmingham; 2. Screening study: multi-centre screening by auscultation or target echocardiography in geographically diverse general practices across the United Kingdom. In each phase, the patient will be identified by auscultation and target echocardiography. Management and onward referral will be at the clinical discretion of the GP. Results of clinical review, investigation, follow-up and management will be recorded at 3 months from that date.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adults aged over 65years attending for influenza vaccination.
- •written informed consent to data collection
Exclusion Criteria
- •known aortic stenosis
- •previous aortic valve repair/replacement
Outcomes
Primary Outcomes
comparison of detection rate of aortic stenosis
Time Frame: From date of examination until follow-up after three months
Comparison of detection rates of aortic stenosis using target auscultation vs detection by target 2D echocardiography.
prevalence of aortic stenosis
Time Frame: From date of examination until follow-up after three months
Determination of the prevalence of aortic stenosis detected on screening performed during flu vaccination.
Secondary Outcomes
- Evaluation of qualitative estimation of calcium burden on 2D echocardiography as a marker of AS severity(three months)
- Calculation of costs in screening with auscultation versus target 2DE in screening for AS to inform future cost-efficacy studies of screening for AS.(three months)