Beta-alanine supplementation in patients with chronic obstructive pulmonary disease (COPD) following a neuromuscular electrical stimulation (NMES) training program.

• Conditions: Chronic obstructive pulmonary disease (COPD); Exercise intolerance; Muscle dysfunction.

• Registration Number: NL-OMON25510
• Lead Sponsor: Board of Directors CIRO

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 68

Inclusion Criteria

COPD, GOLD group B or D
- Modified Medical Research Council (mMRC) dyspnoea score =3
- Clinically stable according to the pulmonary physician, i.e. no exacerbation and/or hospitalization within the previous 4 weeks.
- Age between 40-80 years
- Cycle endurance time is 100-300 seconds.
- Quadriceps muscle strength <80% predicted
- Attending the regular inpatient pulmonary rehabilitation program in CIRO and receiving NMES as the primary muscle training modality.

Exclusion Criteria

Patients will be excluded if they meet at least one of the following criteria: instable cardiac disease, use of anabolic steroids during PR program, history of drugs/alcohol abuse, vegetarianism, inability to understand the Dutch language, self-reported beta-alanine supplementation in the past 3 months, participation in a PR program within the past 12 months, inability to perform a cardiopulmonary exercise test.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Exercise tolerance, defined as cycle endurance time. Cycle endurance time will be determined with the constant work-rate test (CWRT), performed on an ergometer at 75% of the maximal work rate (pre-determined by a cardiopulmonary exercise test; CPET) to volitional exhaustion.