Cardiovascular Changes in Infants of Preeclampsia Mother
- Conditions
- Pre-Eclampsia
- Interventions
- Other: Cardiovascular and immunological changes
- Registration Number
- NCT04699825
- Lead Sponsor
- Assiut University
- Brief Summary
Preeclampsia (hypertension during pregnancy) is a common problem affecting 2-8% of pregnancies worldwide and is typically diagnosed by increased blood pressure and proteinuria. The rate of preeclampsia has increased since the 1980s with higher rates at extreme maternal ages as well as during the first pregnancy. Pre-eclampsia is a serious hypertensive disorder of pregnancy affecting outcomes for both mother and infants. These infants not only have increased risk of neonatal complications including preterm birth, intrauterine growth restriction, abnormal Doppler parameters, feed intolerance, intestinal problem, poor growth, and long term lung condition but also have increased risk of cerebral palsy, abnormal neurodevelopmental outcomes, cardiovascular disease, stroke, and mental disorders during childhood and adulthood.
- Detailed Description
Preeclampsia is diagnosed according to the International Society for the Study of Hypertension in Pregnancy (ISSHP) criteria: BP \> 140/90 on two occasions in previous normotensive mother after 20 weeks of gestation and one of the following; proteinuria in urine \> 0.3 gram/kg/day or acute kidney or liver dysfunction or signs of uterine dysfunction. The onset of preeclampsia can be early before 34 weeks of pregnancy (Early-onset preeclampsia) or late after 34 weeks of pregnancy (Late-onset preeclampsia). Early-onset preeclampsia, especially between 28-32 weeks gestation, is characterized by a high prevalence of microvascular changes in the placenta that makes mothers and their infants are more liable to complication. The pathogenesis of preeclampsia is unclear.
Preeclampsia affects hematopoiesis and the fetal myeloid lineage leading to thrombocytopenia, neutropenia, decrease phagocytic function, decrease T regulatory cells, and an increase in cytotoxic natural killer cells in neonates. Innate and adaptive immunity are regulated by myeloid cells and the immune changes in infants of preeclampsia mothers could lead to increased incidence of neonatal sepsis and the development of chronic inflammatory conditions.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- Infants born from Pregnant women with preeclampsia, their mother willing to give consent.
- 1-Infant with a major heart problem.
- Infants with major congenital and genetic anomalies.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description control group Cardiovascular and immunological changes new-born infants born from mothers with normal pregnancy matched with the same gestational age, sex and race study group Cardiovascular and immunological changes new-born infants born from preeclampsia mother
- Primary Outcome Measures
Name Time Method Cardiac changes within 72 hours after birth cardiac output will be presented by ml/minute
Vascular changes in superior mesenteric and anterior cerebral arteries 72 hours after birth Doppler parameters( peak-systolic velocity, end-diastolic velocity, and mean velocity.
All will be measured in meter/secondCardiac function changes within 72 hours after birth Fractional shortening and ejection fraction will be presented by percentage
- Secondary Outcome Measures
Name Time Method Feeding problem 3 months after birth rate of necrotizing enterocolitis and feeding intolerance
oval all outcomes 3 months Rate of long term lung condition, sepsis, intraventricular hemorrhage and overall mortality
immunological changes cord blood at birth interleukins level