Examination of the glucose metabolism improvement effects by the combination of DPP-4 inhibitor and SGLT2 inhibitor
Not Applicable
- Conditions
- Type 2 diabetes mellitus
- Registration Number
- JPRN-UMIN000030043
- Lead Sponsor
- niversity of Miyazaki , fuculty of medicine, Endocrinology, Metabolism and Diabetes Mellitus, Department of Internal Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patient who cannnot regulary visit hospital 2. Patient with advanced diabetic retinopathy 3. Dialysis patient with diabetes 4. Patient who judged inappropriate due to the complications and treatment by attending doctor
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Glycemic control assessed by meal tolerance test and continuous glucose monitoring on each treatment period
- Secondary Outcome Measures
Name Time Method 1) Insulin secretion capacity and pattern 2) Incretin (GLP-1, GIP) secretion capacity and pattern 3) Glucagon secretion capacity and pattern 4) Ghrelin secretion capacity and pattern 5) Des-acyl ghrelin secretion capacity and pattern 6) C peptide secretion capacity and pattern 7) Changes in urine volume, urinary C peptide, urinary protein, and urinary glucose 8) Changes in body weight, body composition, blood pressure, and pulse rate 9) Changes in renal function, liver function, uric acid, serum lipid, keton body, HOMA-R, and HOMA-beta