Metabolic and vascular adaptations to a positive energy balance
Recruiting
- Conditions
- Insulin resistance, diabetes, obesity and inflammation
- Registration Number
- NL-OMON22377
- Lead Sponsor
- Department of Endocrinology and MetabolismAcademic Medical Center, Amsterdam, the Netherlands
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 8
Inclusion Criteria
1. Age between 30-50
2. normal glucose tolerance (OGTT)
Exclusion Criteria
1. Age < 30- > 50 years
2. Frequent intensive exercise (>2 week) or sedentary life style
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Weight gain and loss<br /><br>- Pro-inflammatory response in adipose tissue and in plasma after initialising a hypercaloric diet<br /><br>- Change in inflammatory response after switching to hypocaloric diet<br /><br>- Insulin sensitivity; Homa-IR and B-cell function<br /><br>- Changes in incretine response in relation to hyper- and hypocaloric diet
- Secondary Outcome Measures
Name Time Method - Changes in symphatic nervous activity<br /><br>- Glucoregulatory hormones