The acute metabolic and cardio respiratory effects of neuromuscular electrical stimulation in critically ill, mechanically ventilated patients: a pilot study.

Completed

Conditions: ICU acquired weakness
critical illness polyneuropathy
nerve damage as a result of critical illness

Registration Number: NL-OMON44494

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 11

Inclusion Criteria

- older than 18 years
- sedated (all levels of sedation) or not yet responsive (Ramsay 5-6)
- Volume supported or pressure supported mechanically ventilated
- respiratory and hemodynamically stable
- signed formed consent by legal representative

Exclusion Criteria

- known systemic neuromuscular disease (eg, Guillain-Barre syndrome)
- ability to actively move the legs
- life expectancy less than 24 hours determined by the physician
- in contact isolation
- pacemaker or implanted cardiac defibrillator
- pregnancy
- body mass index of > 35kg/m2
- condition in the lower extremity preventing treatment (Skin lesions, fractures, amputations, known or suspected malignancy in the legs, myopathy, paresis of the stimulated muscles, epilepsy, allergic reactions to the electrodes, peripheral edemas counteracting NMES, heavy ischaemia of the lower extremities
- corticosteroids usage (>7.5mg/day >3 months)
- positive end-expiratory pressure (PEEP) > 14 cmH2O, Fraction of inspired oxygen (FiO2) >0.6 and the presence of air leakage (Haugen, Chan, & Li, 2007) (Kho et al., 2012, Gruther et al., 2010).
- patients that receive therapeutic hypothermia

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To evaluate the effects of NMES on energy expenditure</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To evaluate the effects of NMES on:<br /><br>- Muscle contraction size as indication of muscle fatigue<br /><br>- Hemodynamics: Blood pressure and heart rate measured continuously<br /><br>- Breathing frequency<br /><br><br /><br>To evaluate the effects of NMES on safety parameters:<br /><br>- Presence or development of metabolic acidosis (pH < 7.35)<br /><br>- Experienced pain during NMES</p><br>