Respiratory, hemodynamic and inflammatory effects of induced HypothermiA using NoVAtherm with extra corporeal membrane ventilator iLA-Activve in patients with acute respiratory distress syndrome (ARDS)

Completed

• Conditions: ARDS; acute lung injury; 10024967

• Registration Number: NL-OMON39735
• Lead Sponsor: ICU volwassen / L.E.I.C.A.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

1) Suffering of a clinical condition associated with ARDS
2) ARDS according to the Berlin definition (P/F < 200 with PEEP > 5 cmH2O; bilateral pulmonary opacities at chest X-ray; respiratory failure not fully explained by cardiac failure or volume overload)
3) Mechanical ventilation with maximum inspiratory pressure levels (Pmax) of > 30 cm H2O, while maintaining tidal volume ventilation of 6-8 ml/kg ideal body weight and permissive hypercapnia with an arterial pH < 7.25.

Exclusion Criteria

1) Contra-indication for (low dose of) heparin
2) Severe shock, requiring norepinephrin dose of > 2 mg/hour
3) Severe hypoxia, requiring referral for extra corporeal membrane oxygenation

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Minute volume ventilation</p><br>