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Clinical Trials/IRCT20230527058306N1
IRCT20230527058306N1RecruitingPhase 3

Investigating the effect of oral acetazolamide compared to placebo on the severity of heart congestion in patients with heart failure

Tehran University of Medical Sciences0 sites130 target enrollmentStarted: TBDLast updated:
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Trial Snapshot

Phase
Phase 3
Status
Recruiting
Enrollment
130
Study OverviewEligibility CriteriaInvestigatorsRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Interventional

Eligibility Criteria

Ages
18 years to 90 years (—)
Sex
All

Inclusion Criteria

  • •Earn at least 8 points from EVEREST score
  • •Patients over 18 years old
  • •The main clinical sign of volume overload includes edema, ascites confirmed by abdominal ultrasound
  • •Pleural effusion confirmed by chest X-ray or chest ultrasound without intravenous furosemide
  • •Maintenance treatment with oral furosemide as a loop diuretic =20 mg for at least one month
  • •Using SGLT2i drugs including canagliflozin, dapagliflozin, and empagliflozin for at least one month

Exclusion Criteria

  • •Systolic blood pressure less than 90 mmHg or mean arterial pressure less than 65 mmHg
  • •Estimated glomerular filtration rate (eGFR) <20 ml/min/1.73 m2
  • •Using any diuretic agent except mineralocorticoid receptor antagonists including spironolactone and eplerenone
  • •Simultaneous diagnosis of acute coronary syndrome, which is characterized by typical chest pain in addition to an increase in troponin level above the 99th percentile or electrocardiographic changes indicating ischemia or hospitalization as unstable angina.

Investigators

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