Effect of Magnesium Sulphate Added to Mepivacaine Hydrochloride on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars: A Randomized Clinical Trial.
试验速览
- 阶段
- 不适用
- 入组人数
- 56
- 主要终点
- success of inferior alveolar nerve block measured using a numerical rating scale (NRS)
研究概览
简要总结
the study is conducted to assess the effect of adding magnesium sulphate to mepivacaine HCl compared to mepivacaine HCl alone on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis in mandibular molars
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 18-55 years old.
- •Systemically healthy patient (ASA I or II).
- •Mandibular molar teeth with:
- •Preoperative sharp pain.
- •No widening in the periodontal ligament (PDL).
- •Vital response of pulp tissue to cold pulp tester (ethyl chloride spray)
- •Fully formed roots.
- •Positive patient's acceptance for participation in the study.
排除标准
- •Patients who had used any type of analgesic medication during the preceding 12 hours before the treatment.
- •Pregnant or nursing females.
- •Patients having significant systemic disorder (ASA III or IV).
- •Drug abusers and subjects who were on antidepressant medication.
- •Re-treatment cases.
- •Patients with a contraindication for the use of magnesium sulphate or those known to be allergic to any of the study medications.
研究组 & 干预措施
megnesium sulphate
Injection of 1.8 mL of an anaesthetic solution containing 1% magnesium sulphate , and 1.8% mepivacaine HCL with .06mg Levonordefrin HCl during inferior alveolar nerve block.
干预措施: Magnesium sulfate (Drug)
mepivacaine HCl
Injection of 1.8 mL of a local anaesthetic solution containing 1.8% mepivacaine HCL with .06mg Levonordefrin HCL during inferior alveolar nerve block
干预措施: Mepivacaine-Levonordefrin Hydrochloride (Drug)
结局指标
主要结局
success of inferior alveolar nerve block measured using a numerical rating scale (NRS)
时间窗: 15 minutes after injection
Intensity of pain 15 minutes after injection during access cavity and initial file placement is recorded by the patient using a numerical rating scale(where 0= no pain ,1-3 =mild pain ,4-6= moderate pain and 7-9= severe pain )
次要结局
未报告次要终点
研究者
Alaa Ibrahim Ibrahim Ghazy Mekhimar
Resident at faculty of dentistry, Cairo University
Cairo University