Identifying Risk Factors for Gram-negative Resistance for HAP/VAP in the Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 132
- 试验地点
- 1
- 主要终点
- Rate of Gram-negative isolate resistance to piperacillin-tazobactam, cefepime, meropenem
研究概览
简要总结
Single center, retrospective chart review. Patients admitted to MDMC ICU from 4/1/2017 to 6/30/2020 will be identified through the electronic medical record utilizing ICD codes for HAP and VAP.
详细描述
Single center, retrospective chart review. Patients admitted to MDMC ICU from 4/1/2017 to 6/30/2020 will be identified through the electronic medical record utilizing ICD codes for HAP and VAP. Patients with respiratory culture data signifying a Gram-negative organism as the cause of HAP/VAP will be analyzed as described below if study inclusion criteria is met. Minimum inhibitory concentration (MIC) data will interpreted per Clinical & Laboratory Standards Institute (CLSI) standards to determine local patterns of resistance. Multivariable logistic regression will be performed to determine risk factors for piperacillin-tazobactam, cefepime or meropenem resistant Gram-negative isolates. Project target date of completion and close-out is May 2021.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU, Neuro critical care unit admission
- •Diagnosis of HAP or VAP
- •Respiratory culture positive for Gram-negative organism
排除标准
- •ICU length of stay <48 hours prior to HAP/VAP
- •Culture or MIC data unavailable
结局指标
主要结局
Rate of Gram-negative isolate resistance to piperacillin-tazobactam, cefepime, meropenem
时间窗: April 2017 - May 2020
Percentage
次要结局
- duration of mechanical ventilation(April 2017 - May 2020)
- Rate of susceptibility to non-beta lactam antipseudomonal agents(April 2017 - May 2020)
- need for mechanical ventilation(April 2017 - May 2020)
- development of septic shock(April 2017 - May 2020)
- ICU length of stay(April 2017 - May 2020)
- hospital length of stay(April 2017 - May 2020)
- in-hospital mortality(April 2017 - May 2020)