Pathological evaluation of asthma with rhinitis or rhinosinusitis by measuring fractional exhaled nitric oxide (FeNO)and nasal nitric oxide (nasal NO). - Eevaluation of asthma by nasal NO.
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 346
研究概览
简要总结
asa NO values are signignificantly higher in asthmatic patients with rhinitis than those without upper airway diseases or those with chronic rhinosinusitis, suggesting the utility of nasal NO measurements for diagnosing comorbid rhinitis in asthmatic patients. No significant differences were found in nasal NO values between those wit and without asthma. Therefore, nasal NO values seem to be specific to upper airway inflammation. Nasal No values did not associate with the severity of rhinitis. In contrast, nasal NO values were inversely correlated with severity of rhinosinusitis (sinus CT scoring) and asthma control (ACQ scores). When evaluating other biomarkers, serum periostin levels were higher in patients with CRS compared to those without upper airway diseases or those with rhinitis.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 16years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. Patients who are considered to have infectious disease like mycobacterium tuberculosis. 2. Current smoker, and ex-smoker with smoking history more than 5 pack-year. 3. Patients who can not perform laboratory tests correctly. 4. Patients who has oral steroids at the registration period. Except for the patients who had 2 weeks washout peroiod prior to registration. 5. Patients who was judged as inappropriate by investigators