The efficacy of synbiotic supplements containing Bacillus coagulans and inulin with low FODMAP diet compared with low FODMAP diet alone on inflammatory factors, clinical outcomes and quality of life in patients with irritable bowel syndrome

Shahid Beheshti University of Medical Sciences0 个研究点目标入组 50 人开始时间: 待定最近更新: 2019年1月14日

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•18-65 years
•Patients with irritable bowel syndrome, according to gastroenterologist diagnosed according to the ROME- IV criteria (1.Improvement with defecation 2.Onset associated with a change in stool frequency 3.Onset associated with a change in stool form (appearance) At least three days a month, three months a year and no pathological findings in the clinical investigating)
•lack of any organic intestinal disease(diagnosed by last 5 years ago colonoscopy) and intestinal infections(diagnosed by stool culture).
•No medical history of chronic gastrointestinal and colorectal disease
•Absence of any major bowel surgery
•Absence of regular use of laxatives or antidiarrheal drugs
•No chronic use of antibiotics, corticosteroids and immunosuppressants
•No usage of drugs that modifying the digestive motility such as metoclopramide, cisapride, diphenoxylate,…
•No usage of drugs that increased bleeding of intestinal mucosa such as aspirin, warfarin, heparin,…
•No history of breast cancer in patient or in first-degree relatives of a person
•Absence of severe mental or behavioral disorder
•Absence of nicotine and its derivatives use in last 6 monthsNo usage of NSAIDs and aspirin in last week(influence on gut permeability)

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