Ganirelix in insemination cycles of women with premature luteinizatio
Phase 4
Completed
- Conditions
- infertilityintrauterine inseminationReproductive Health and Childbirth - Fertility including in vitro fertilisation
- Registration Number
- ACTRN12612000153819
- Lead Sponsor
- Mersin University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 114
Inclusion Criteria
The main inclusion criteria were age between 18 and 38 years, primary or secondary infertility lasting for > 12 months, normal thyroid function, normal prolactin levels and normal uterine cavity and bilateral tubal patency assessed by hysterosalpingography
Exclusion Criteria
severe male factor infertility (sperm concentration <10 x106 or strict morphology <4%), stage III or IVendometriosis, baseline FSH > 10 IU/L.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Two weeks after the intrauterine insemination procedure, an hCG assay was performed. If the assay was positive, transvaginal ultrasonography was scheduled for 2-3 weeks later. <br>Only a positive hCG was determined as biochemical pregnancy, both positive hCG assay and determination of embriyonic heartbeat was accepted as clinical pregnancy. Ultrasonography was done at 12-16th week to establish ongoing pregnancy.[two years period from June 2007<br>Two weeks after the intrauterine insemination procedure, an hCG assay was performed.<br>Ultrasonography was done at 12-16th week to establish ongoing pregnancy]
- Secondary Outcome Measures
Name Time Method uteinizing hormone (LH) levels > 10 IU/L and progesterone (PRG) levels > 1 ng/ml was considered as premature luteinization.<br>PRG level was determined by competitive electro-chemoluminescent immunoassay method by auto-analyzer. LH levels were determined by sandwich electro-chemoluminescent immunoassay method by the same autoanalyzer.[two years period from June 2007<br>LH and PRG levels were determined 10-14 days after menstruation]