IRCT20181022041406N1
Completed
未知
Catheter directed thrombolysis versus anticoagulation only in patients with Intermediate-high risk pulmonary emboli-A randomized clinical trial
Rajaie Cardiovascular Medical and Research Center0 sites288 target enrollmentTBD
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Pulmonary emboli.
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
- Enrollment
- 288
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Men and women \= 18 year\-old
- •Acute pulmonary emboli must be confirmed with pulmonary CT angiography
- •Symptoms onset \= 14 days
- •Elevated pro b\-type natriuretic peptide and cardiac troponin
- •Right ventricle/left ventricle ratio in pulmonary CT angiography \>0\.9
- •simplified pulmonary embolism severity index score \>\=1
- •Less than 48 hours of anticoagulation therapy
Exclusion Criteria
- •Pulmonary emboli diagnosed with other modalities than pulmonary CT angiography
- •High risk (massive) pulmonary Emboli
- •Segmental pulmonary emboli
- •Patient with terminal illness
- •Surgery within 2 weeks
- •Severe renal dysfunction (creatinine clearance \[CrCl] below 30 mL/min)
- •Platelet count \<50\.000
- •Thrombolytic contraindication
- •Concomitant right heart thrombosis
- •Pre and post catheter directed thrombolysis echocardiography exam not possible
Outcomes
Primary Outcomes
Not specified
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