Vitamin D Supplementation Prevents Elderly Pneumonia
- Conditions
- Bacterial Pneumonia
- Interventions
- Dietary Supplement: Vitamin D3
- Registration Number
- NCT00877422
- Lead Sponsor
- Tohoku University
- Brief Summary
Pneumonia is the fourth leading cause of death and frequently occurs in institutionalized elderly people in Japan. Recently, several clinical and experimental studies have reported the importance of vitamin D in the regulation of immune functions and its deficiency is associated with susceptibility to some infections. In the present study, the investigators hypothesize that deficiency of serum vitamin D is associated with development of pneumonia, and supplementation of vitamin D may lower the incidence of pneumonia and prolong survival in institutionalized elderly subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- Subjects are more than 65 years old and were resident in the facility for at least 6 months.
- Subjects have no conditions known to interfere with vitamin D metabolism.
-
Subjects are excluded if they have:
- renal failure
- hepatic failure
- hyper- or hypo-parathyroidism
- HIV infection, or malignant diseases
-
Subjects are also excluded if they are taking corticosteroid, thiazide diuretics, or supplementary vitamins.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group B Vitamin D3 Group B is identified as serum vitamin D level less than 16 ng/dl and is supplemented with vitamin D3.
- Primary Outcome Measures
Name Time Method prevalence of pneumonia one year
- Secondary Outcome Measures
Name Time Method all cause mortality one year
Trial Locations
- Locations (1)
Institute of Development, Aging and Cancer, Tohoku University
🇯🇵1-1,Seiryo-machi,Aoba-ku,Sendai, Japan