Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis

Phase 3

Completed

Conditions: Arthritis, Rheumatoid

Interventions: Drug: CP-690,550

Registration Number: NCT00413699

Lead Sponsor: Pfizer

Brief Summary: The purpose of this study is to determine the long-term effectiveness and safety of CP-690,550 for the treatment of rheumatoid arthritis. Subjects are eligible for this study only after participating in another "qualifying" study of CP-690,550

A sub-study will be conducted within the A3921024 study, this study will evaluate the immune response to pneumococcal and influenza vaccines in patients receiving CP-690,550

Detailed Description: Not available

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 4488

Inclusion Criteria

Subjects who have participated in a randomized "qualifying" study of CP-690,550 for the treatment of rheumatoid arthritis

Vaccine sub-study visit

Subjects actively participating in Study A3921024 must have completed at least 3 months of continuous 10 mg BID CP-690,550 treatment in A3921024 as defined by >80% compliance with prescribed dose consumption of CP-690,550 over the previous 3 months.

Exclusion Criteria

Serious medical conditions that would make treatment with CP-690,550 potentially unsafe

Vaccine sub-study visit

Any documented influenza or pneumococcal infection within the last 3 months prior to randomization in this study
Received any vaccine within 1 month prior to randomization in this study
Received an influenza vaccine within 6 months or a pneumococcal vaccine within 5 years of randomization in this study.

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Open-Label Active Treatment Enrolled from Phase 3	CP-690,550	Patients enrolling from Phase 3 studies
Open-Label Active Treatment Enrolled from Phase 2	CP-690,550	Patients enrolling from Phase 2 studies

Primary Outcome Measures

Name	Time	Method
Initial Period: Primary Endpoints Were Standard Laboratory Safety Data (Chemistry, Hematology, Etc.) and Adverse Event (AE) Reports	Includes laboratory test abnormality data for all visits and adverse event data up to 999 days after last dose of study drug	Treatment-emergent non serious AEs by System Organ Class (SOC) (all causalities) and Laboratory Test Abnormalities (without regard to baseline) The stated number of participants analyzed was the total number of participants in each group (AEs). The actual number of participants analyzed for each laboratory parameter varied, and is provided for each. Abs=absolute; ALT=alanine aminotransferase; AST=aspartate aminotransferase; ESR=erythrocyte sedimentation rate; GGT=gamma glutamyl transferase; hgb=hemoglobin; HDL=high density lipids; LDL=low density lipids; LLN=lower limit of normal; qual=qualitative; Tot=total; ULN=upper limit of normal; WBC=white blood cell
Extension Period: Number of Participants With Treatment Emergent Adverse Events (AEs), Serious Adverse Events (SAEs)	Baseline (Day 1 at Entry of Extension Period) up to 28 days after last study drug dose in Extension Period (13 Months)	An AE was any untoward medical occurrence in a participant who received study drug without regard to possibility of causal relationship. SAE was an AE resulting in any of the following outcomes or deemed significant for any other reason: death; initial or prolonged inpatient hospitalization; life-threatening experience (immediate risk of dying); persistent or significant disability/incapacity; congenital anomaly. A treatment emergent AE was defined as an event that emerged during the treatment period that was absent before treatment, or worsened during the treatment period relative to the pretreatment state. AEs included both serious and non-serious adverse events.
Extension Period: Number of Participants With Laboratory Test Abnormalities	Baseline (Day 1 at Entry of Extension Period) up to 28 days after last study drug dose in Extension Period (13 Months)	Criteria for laboratory abnormalities: hemoglobin (Hg), hematocrit, red blood cell (RBC), high density lipoprotein (HDL) cholesterol:\<0.8\lower limit of normal (LLN), platelet\<0.5\LLN/\>1.75\upper limit of normal (ULN), white blood cell (WBC)\<0.6\LLN/\>1.5\ULN, lymphocyte, neutrophil, protein, albumin \<0.8\LLN/\>1.2\ULN, basophil, eosinophil, monocyte, low density lipoprotein (LDL) cholesterol: \>1.2\ULN; bilirubin\>1.5\ULN, aspartate amino transferase(AT), alanine AT, gammaglutamyl transferase, alkaline phosphatase:\>3.0\ULN; blood urea nitrogen, creatinine, cholesterol, triglyceride:\>1.3\ULN; sodium \<0.95\LLN/\>1.05\ULN, potassium, chloride, calcium, bicarbonate: \<0.9\LLN/\>1.1\ULN; glucose\<0.6\LLN/\>1.5\ULN; Urine (specific gravity\<1.003/\>1.030, pH\<4.5/\>8, glucose, ketone, protein, blood/Hg(\>=1; RBC, WBC\>=20; creatinine kinase\>2\ULN).
Initial Period: The Long Term Safety and Tolerability of CP-690,550 5 Milligrams (mg) Twice Daily (BID) and 10 mg BID for the Treatment of Rheumatoid Arthritis	Includes AEs for every visit and up to 999 days after last dose of study drug	Treatment-emergent AEs by SOC (all causalities) - all participants, by time. Data presented for Post Month 96 includes data up to and including Month 114.
Extension Period: Percentage of Participants With Adverse Events and Who Discontinued Treatment Due to Adverse Events to Assess Long-term Safety and Tolerability of Tofacitinib	Baseline (Day 1 at Entry of Extension Period) up to Month 6 of Extension Period; Month 6 of Extension Period to Month 12 of Extension Period	Long term safety and tolerability of Tofacitinib was measured as following: percentage (%) of participants with AEs, percentage of participants who discontinued due to AEs. An AE is any untoward medical occurrence in participant who received study drug without regard to possibility of causal relationship.

Secondary Outcome Measures

Name	Time	Method
Extension Period: Change From Baseline in Disease Activity Score (DAS) 28-3 C-Reactive Protein (CRP)(DAS28-3 CRP) and DAS28-4 Erythrocyte Sedimentation Rate (ESR)(DAS28-4 ESR) at Month 3, 6, 9 and 12	Baseline (Month 0 at the entry of Initial period); Month 3, 6, 9 and 12 of Extension Period	DAS28 is composite score, calculated using mathematical formula, derived from: 1) tender/painful joints count, out of 28 joints (TJC28), 2) swollen joints count, out of 28 joints (SJC28), 3) blood marker of inflammation (ESR \[millimeter per hour\] or CRP \[milligram per liter\]). DAS28-4 also include score of general health (GH). GH is general health or participants' global assessment of disease activity on 100 mm visual analog scale (GH score: 0 mm \[very well\] to 100 mm \[extremely bad\], higher scores = worse health condition). DAS28-3(CRP) = (0.56\sqrt\[TJC28\] + 0.28\sqrt\[SJC28\] + 0.36\ln\[CRP+1\]) \1.10 + 1.15) and DAS28-4(ESR) = (0.56\sqrt\[TJC28\] + 0.28\sqrt\[SJC28\] + 0.70\ln\[ESR\] + 0.014\GH), where sqrt = square root, ln = natural logarithm. DAS28-4 ESR and DAS28-3 CRP: score ranges from 0 (none) to 9.4 (extreme disease activity), with a higher score indicating more disease activity. Score of \<=3.2 indicate low disease activity and score of \<2.6 indicate disease remission.
Initial Period: Number (%) of Participants With DAS28-4 (ESR) and DAS28-3 (CRP) <2.6 and ≤3.2	Every visit until study completion	Percent participants with DAS28-4 (ESR) \<2.6 and ≤3.2 and percent participants with DAS28-3 (CRP) \<2.6 and ≤3.2. The stated number of participants analyzed was the total number of participants in each group. The actual number of participants analyzed on each occasion varied, and is provided for each visit presented. DAS28 is a composite score, calculated using a mathematical formula, and is derived from the number of tender/painful joints (out of 28), number of swollen joints (out of 28), and a blood marker of inflammation (ESR or CRP). DAS28-4 also includes a score of general health in the formula. The score range is from 0 to 9.4, with a higher score indicating more disease activity. A score of \>5.1 indicates active disease, a score of ≤3.2 indicates low disease activity, and a score of \<2.6 indicates disease remission.
Initial Period: Percentage of Patients With American College of Rheumatology (ACR) 20, 50, and 70 Responses	Every visit until study completion	The stated number of participants analyzed was the total number of participants in each group. The actual number of participants analyzed on each occasion varied, and is provided for each visit presented. ACR20 is defined as a 20% improvement from baseline in tender/painful joint count and swollen joint count, and at least 3 of the following 5 variables: Subject's Global Assessment of Arthritis, Physician's Global Assessment of Arthritis, Subject's Assessment of Arthritis Pain, Health Assessment Questionnaire - Disability Index, C-Reactive Protein (CRP). ACR50 is a 50% improvement and ACR70 a 70% improvement in these variables.
Extension Period: Percentage of Participants With American College of Rheumatology (ACR) 20, 50, and 70 Responses	Month 3, 6, 9 and 12 of Extension Period	ACR20=20 percent (%) improvement from baseline (Month 0 at entry of Initial Period) in tender/painful joint count and swollen joint count, and in at least 3 of 5 variables: participant's global assessment of arthritis (PtGA), physician's global assessment of arthritis (PGA), participant's assessment of arthritis pain (PtA), HAQ-DI, C-reactive protein. ACR50 is a 50% improvement and ACR70 is a 70% improvement in these variables. PtGA: participant assessed overall disease activity, score: 0 (no arthritis) to 10 (extreme arthritis), higher score=more arthritis. PGA: physician judged participant's overall disease activity, score: 0 (no arthritis) to 10 (extreme arthritis), higher score=more arthritis. PtA: participant assessed arthritis pain by 100 millimeter (mm) visual analogue scale, score: 0 mm (no pain) to 100 mm (extreme pain), higher score=more pain. HAQ-DI: functional disability evaluation, score: 0 (no difficulty) to 3 (extreme difficulty), higher score=more disability.
Initial Period: Area Under American College of Rheumatology (ACR) n Curve	Not applicable as no data were collected for this endpoint.	No data were collected for this endpoint because it was removed from the protocol in a previous amendment.
Initial Period: Disease Activity Score (DAS)28 (C-reactive Protein [CRP]) and DAS28 (Erythrocyte Sedimentation Rate [ESR])	Every visit until study completion	Descriptive statistics for DAS28-3 (CRP) and DAS28-4 (ESR). The stated number of participants analyzed was the total number of participants in each group. The actual number of participants analyzed on each occasion varied, and is provided for each visit presented. DAS28 is a composite score, calculated using a mathematical formula, and is derived from the number of tender/painful joints (out of 28), number of swollen joints (out of 28), and a blood marker of inflammation (ESR or CRP). DAS28-4 also includes a score of general health in the formula. The score range is from 0 to 9.4, with a higher score indicating more disease activity. A score of \>5.1 indicates active disease, a score of ≤3.2 indicates low disease activity, and a score of \<2.6 indicates disease remission.
Extension Period: Percentage of Participants With DAS28-4 (ESR) and DAS28-3 (CRP) Less Than (<) 2.6 and Less Than or (<=) 3.2	Baseline (Day 1 at the entry of Extension period); Month 3, 6, 9 and 12 of Extension Period	DAS28 is composite score, calculated using mathematical formula, derived from: 1) tender/painful joints count, out of 28 joints (TJC28), 2) swollen joints count, out of 28 joints (SJC28), 3) blood marker of inflammation (ESR \[millimeter per hour\] or CRP \[milligram per liter\]). DAS28-4 also include score of GH. GH is general health or participants' global assessment of disease activity on 100 mm visual analog scale (GH score: 0 mm \[very well\] to 100 mm \[extremely bad\], higher scores = worse health condition). DAS28-3(CRP) = (0.56\sqrt\[TJC28\] + 0.28\sqrt\[SJC28\] + 0.36\ln\[CRP+1\]) \1.10 + 1.15) and DAS28-4(ESR) = (0.56\sqrt\[TJC28\] + 0.28\sqrt\[SJC28\] + 0.70\ln\[ESR\] + 0.014\GH), where sqrt = square root, ln = natural logarithm. DAS28-4 ESR and DAS28-3 CRP: score range is from 0 (none) to 9.4 (extreme disease activity), with a higher score indicating more disease activity. Score of \<=3.2 indicate low disease activity and score of \<2.6 indicate disease remission.
Initial Period: Health Assessment Questionnaire - Disability Index (HAQ-DI) Score	Every visit until study completion	Change from baseline by visit. HAQ-DI scores range from 0 to 3, where lower score implies less disease. A reduction from baseline in score indicates an improvement in condition. A clinically meaningful decrease from baseline is defined as a decrease of at least 0.22 units. The stated number of participants analyzed was the total number of participants in each group. The actual number of participants analyzed on each occasion varied, and is provided for each visit presented.
Extension Period: Change From Baseline in Health Assessment Questionnaire - Disability Index (HAQ-DI) Score at Month 3, 6, 9 and 12	Baseline (Month 0 at the entry of Initial Period); Month 3, 6, 9, and 12 of Extension Period	HAQ-DI assesses the degree of difficulty a participant has experienced during the past week in 8 categories of daily living activities: dressing/grooming; arising; eating; walking; reach; grip; hygiene; and other activities. Each activity category consisted of 2-3 questionnaire. Each questionnaire was scored on a 4-point scale from 0 to 3: 0=no difficulty; 1=some difficulty; 2=much difficulty; 3=unable to do. Any activity that required assistance from another individual or required the use of an assistive device was adjusted to a score of 2 to represent a more limited functional status. Overall score was computed as the sum of total scores divided by the number of questionnaire answered. Total possible HAQ-DI score range: 0 (least difficulty) and 3 (extreme difficulty), where higher scores indicate more difficulty while performing daily living activities.
Initial Period: Short-Form-36 Health Survey (SF-36) Score	Every visit until study completion	Change from Baseline for Physical Component and Mental Component Scores by visit. SF-36 is a health status measure of 8 general health domains, each scored on a 0 to 100 scale: physical functioning, role physical, bodily pain, general health, vitality, social functioning, role emotional, and mental health. These domains can be summarized as physical and mental component scores. The domain scores were "normed" and the resulting component scores treated as Z-scores with a scale of negative to positive infinity. A higher score implies less disease. The greater the change from baseline, the greater the improvement. The stated number of participants analyzed was the total number of participants in each group. The actual number of participants analyzed on each occasion varied, and is provided for each visit presented.
Initial Period: FACIT Fatigue Scale, EuroQol EQ 5D, Work Limitations Questionnaire, and RA Healthcare Resource Utilization Questionnaire (RA-HCRU)	Every visit until study completion	Change from Baseline Scores for each: FACIT Fatigue Scale (score range 0 to 52, higher score indicates higher quality of life and an increase from baseline score indicates improvement), EuroQol EQ 5D (index values derived from a measure of central tendency and a measure of dispersion, an increase from baseline indicates improvement, score range 0 to 1), Work Limitations (WL) Physical Demands (covers ability to perform job tasks that involve bodily strength, a decrease from baseline indicates improvement, score range 0 to 100, higher scores indicating greater limitation), and RA Healthcare Resource Utilization Work Performance in Past 3 Months on Days Bothered by RA (assesses healthcare use over previous 3 months, a decrease from baseline indicates improvement, score range 0 to 10). The stated number of participants analyzed was the total number of participants in each group. The actual number of participants analyzed on each occasion varied, and is provided for each visit presented.
Initial Period: Preservation of Joint Structure in Participants Who Had Baseline Radiographs Obtained in Their Qualifying Index Study	Every 6 months until study completion	Modified Total Sharp Score per visit. Baseline score was the last available assessment from the index study. The Modified Total Sharp Score measures disease progression; increased scores indicate disease progression. Score range 0 (normal) to 448 (worst possible total score). The stated number of participants analyzed was the total number of participants in each group. The actual number of participants analyzed on each occasion varied, and is provided for each visit presented. TSS=Total Sharp Score
Vaccine Sub-study. Percent Achieving a Satisfactory Humoral Response to the Pneumococcal Vaccine as Defined by ≥ 2-fold Increase in Antibody Concentrations	From vaccine sub-study visit 2 (baseline) to sub-study visit 4	Number (%) of participants achieving a satisfactory humoral response to the pneumococcal vaccine as defined by ≥2-fold increase in antibody concentration from vaccine sub-study visit 2 (vaccination baseline) in ≥6 of 12 anti-pneumococcal antigens (serotypes 1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F) The number of participants was the number with a determinate antibody titer to the given vaccine antigen within the population. 95% CI is based on Clopper-Pearson exact method for response rate.
Vaccine Sub-study. Percent Achieving a Satisfactory Humoral Response to the Seasonal Influenza Vaccine as Defined by ≥ 4-fold Increase in Antibody Titers	From vaccine sub-study visit 2 (baseline) to sub-study visit 4	Number of participants achieving a satisfactory humoral response to the seasonal influenza vaccine as defined by ≥4-fold increase in antibody titers from visit 2 (vaccination baseline) in ≥2 of 3 influenza antigens (HAI B, HAI H1N1, and HAI H3N2) The number of participants was the number with a determinate antibody titer to the given vaccine antigen within the population. 95% CI is based on Clopper-Pearson exact method for response rate.
Vaccine Sub-study. Percentage of Participants Achieving Protective Antibody Titers to the Seasonal Influenza Vaccine as Measured by a Hemagglutination Inhibition (HI) Assay Titer of ≥ 1:40 in ≥ 2 of 3 Influenza Antigens at Vaccine Sub-study Visit 3 and 4	From vaccine sub-study visit 2 (baseline) to sub-study visit 4	Number (%) of participants achieving protective antibody titers to the seasonal influenza vaccine as measured by an HAI assay titer of ≥1:40 in ≥2 of 3 influenza antigens measured at vaccine sub-study visits 3 and 4. The number of participants was the number with a determinate antibody titer to the given vaccine antigen within the population. 95% CI is based on Clopper-Pearson exact method for response rate.
Vaccine Sub-study. Percentage of Participants Who Respond to Each of the 12 Pneumococcal Antigens as Defined by ≥ 2-fold Increase in Antibody Concentrations From Vaccine Sub-study Visit 2 (Vaccination Baseline) Measured at Vaccine Sub-study Visit 4	From vaccine sub-study visit 2 (baseline) to sub-study visit 4	Number (%) of participants achieving a satisfactory humoral response to the pneumococcal vaccine as defined by ≥2-fold increase in antibody concentration from vaccine sub-study visit 2 (vaccination baseline) in ≥6 of 12 anti-pneumococcal antigens (serotypes 1, 3, 4, 5, 6B, 7F, 9V, 14, 18C, 19A, 19F, 23F) The number of participants was the number with a determinate antibody titer to the given vaccine antigen within the population. 95% CI is based on Clopper-Pearson exact method for response rate.
Vaccine Sub-study. Percentage of Participants Who Respond to Each of the 3 Influenza Antigens as Defined by ≥ 4-fold Increase in Antibody Titers From Vaccine Sub-study Visit 2 (Vaccination Baseline) Measured at Vaccine Sub-study Visit 4	From vaccine sub-study visit 2 (baseline) to sub-study visit 4	Number (%) of participants achieving a satisfactory humoral response to the seasonal influenza vaccine defined as ≥4-fold increase in antibody titers from visit 2 (vaccination baseline) in ≥2 of 3 influenza antigens (HAI B, HAI H1N1, and HAI H3N2). The number of participants was the number with a determinate antibody titer to the given vaccine antigen within the population. 95% CI is based on Clopper-Pearson exact method for response rate.
Vaccine Sub-study. Fold Increase of Anti-pneumococcal Antibody Levels to Each of the 12 Pneumococcal Antigens Above Vaccination Baseline Values (Vaccine Sub-study Visit 2) at Vaccine Sub-study Visit 4	From vaccine sub-study visit 2 (baseline) to sub-study visit 4	Geometric Mean Fold Increase From Baseline of Pneumococcal Antigens Measured at Visit 4. n was the number of participants with valid and determinate assay results for the specified serotype at the given visit. The stated number of participants analyzed was the total number of participants. The actual number of participants analyzed for some serotypes varied, and is provided where it differed from the total number of participants. Confidence Intervals (CIs) were back transformations of a CI based on the Student t distribution for the mean logarithm of the concentrations.
Vaccine Sub-study. Fold Increase of Anti-influenza Antibody Levels to Each of the 3 Influenza Antigens Above Vaccination Baseline Values (Vaccine Sub-study Visit 2) at Vaccine Sub-study Visit 4	From vaccine sub-study visit 2 (baseline) to sub-study visit 4	Geometric Mean Fold Increase From Baseline of Influenza Antigens Measured at Visit 4. n was the number of participants with valid and determinate assay results for the specified HAI strain at the given visit. Confidence Intervals (CIs) were back transformations of a CI based on the Student t distribution for the mean logarithm of the titers.
Vaccine Sub-study. Concentrations of Anti-pneumococcal Antibodies at Vaccine Sub-study Visit 3 and 4	From vaccine sub-study visit 2 (baseline) to sub-study visit 4	Mean pneumococcal concentrations (ug/mL) at vaccine baseline (visit 2) and post-vaccination visits (visits 3 and 4) by serotype. The stated number of participants analyzed was the total number of participants in each group. The actual number of participants analyzed for each serotype varied, and is provided for each individually. ug/mL=micrograms per milliliter
Vaccine Sub-study. Titers of Anti-influenza Antibodies at Vaccine Sub-study Visit 3 and 4	From vaccine sub-study visit 2 (baseline) to sub-study visit 4	Mean influenza antibody titers at visits 3 and 4.

Trial Locations

Locations (464): NEA Baptist Clinic
🇺🇸
Jonesboro, Arkansas, United States
Rheumatology Associates
🇺🇸
Portland, Maine, United States
Arthritis Research and Care Foundation Centre for Rheumatic Diseases
🇮🇳
Pune, Maharashtra, India
University of Southern California (USC) Norris Comprehensive Cancer Center
🇺🇸
Los Angeles, California, United States
Ronald Reagan UCLA Medical Center, Drug Information Center
🇺🇸
Los Angeles, California, United States
Arthritis and Rheumatology of Georgia P.C.
🇺🇸
Atlanta, Georgia, United States
Clinica de Enfermedades Cronicas y Procedimientos Especiales SC
🇲🇽
Morelia, Michoacan, Mexico
Orszagos Reumatologiai Es Fizioterapias Intezet
🇭🇺
Budapest, Hungary
Jehangir Clinical Development Centre Pvt. Ltd.
🇮🇳
Pune, Maharashtra, India
Queen Elizabeth Hospital
🇲🇾
Kota Kinabalu, Sabah, Malaysia
Revmatologichno Otdelenie, MBAL - Plovdiv
🇧🇬
Plovdiv, Bulgaria
Hospital Regional de Rancagua
🇨🇱
Rancagua, Chile
Centro de Reumatologia y Osteoporosis, Cartago
🇨🇷
Cartago, Costa Rica
University Hospital Center Osijek
🇭🇷
Osijek, Croatia
University Hospital Center Zagreb
🇭🇷
Zagreb, Croatia
Virginia Mason Medical Center
🇺🇸
Seattle, Washington, United States
Med Investigations, Inc.
🇺🇸
Fair Oaks, California, United States
Arthrocare, Arthritis Care & Research, PC
🇺🇸
Gilbert, Arizona, United States
Rockford Orthopedic Associates
🇺🇸
Rockford, Illinois, United States
Deerbrook Medical Associates
🇺🇸
Vernon Hills, Illinois, United States
St. Luke's Clinic
🇺🇸
Boise, Idaho, United States
Marietta Rheumatology Associates
🇺🇸
Marietta, Georgia, United States
CHI St. Vincent Medical Group Hot Springs
🇺🇸
Hot Springs, Arkansas, United States
Ochsner Clinic Foundation - Baton Rouge
🇺🇸
Baton Rouge, Louisiana, United States
Lovelace Scientific Resources
🇺🇸
Venice, Florida, United States
New England Research Associates, LLC
🇺🇸
Trumbull, Connecticut, United States
Jeffrey D. Lieberman, MD, PC
🇺🇸
Decatur, Georgia, United States
Miami Research Associates
🇺🇸
South Miami, Florida, United States
Florida Medical Clinic, P.A.
🇺🇸
Zephyrhills, Florida, United States
BayCare Outpatient Imaging at Bardmoor
🇺🇸
Largo, Florida, United States
West Broward Rheumatology Associates, Inc.
🇺🇸
Tamarac, Florida, United States
St. Luke's Clinic - Rheumatology
🇺🇸
Boise, Idaho, United States
Loyola University Medical Center
🇺🇸
Maywood, Illinois, United States
Asheville Rheumatology & Osteoporosis Research Associates, PA
🇺🇸
Asheville, North Carolina, United States
Venice Arthritis Center
🇺🇸
Venice, Florida, United States
St. Luke's Clinic - Rhematology
🇺🇸
Meridian, Idaho, United States
Rheumatology Associates of North Jersey
🇺🇸
Teaneck, New Jersey, United States
AAIR Research Center
🇺🇸
Rochester, New York, United States
Arthritis, Rheumatic & Back Disease Associates
🇺🇸
Voorhees, New Jersey, United States
Metroplex Clinical Research Center
🇺🇸
Dallas, Texas, United States
Arthritis Associates, PLLC
🇺🇸
Hixson, Tennessee, United States
Regional Rheumatology Associates
🇺🇸
Binghamton, New York, United States
Southern Tier Arthritis and Rheumatism
🇺🇸
Olean, New York, United States
STAT Research, Inc.
🇺🇸
Dayton, Ohio, United States
Office of David R. Mandel, MD, Inc.
🇺🇸
Mayfield, Ohio, United States
Dartmouth-Hitchcock Medical Center
🇺🇸
Lebanon, New Hampshire, United States
Mountain State Clinical Research
🇺🇸
Clarksburg, West Virginia, United States
The Center for Rheumatology and Bone Research
🇺🇸
Wheaton, Maryland, United States
Trinity Health Center - Medical Arts
🇺🇸
Minot, North Dakota, United States
The Center for Rheumatology, LLP
🇺🇸
Albany, New York, United States
Piedmont Arthritis Clinic, PA
🇺🇸
Greenville, South Carolina, United States
Centro de Investigaciones Reumatologicas y Osteologicas -CIRO
🇦🇷
Buenos Aires, Caba, Argentina
Asheville Rheumatology & Osteoporosis Research Associates, P.A.
🇺🇸
Asheville, North Carolina, United States
Buffalo Rheumatology and Medicine, PLLC
🇺🇸
Orchard Park, New York, United States
PMG Research Hickory, LLC
🇺🇸
Hickory, North Carolina, United States
Baylor Research Institute
🇺🇸
Dallas, Texas, United States
Universitair Ziekenhuis Gent - Reumatologie
🇧🇪
Gent, Oost-vlaanderen, Belgium
Consultorios Reumatologicos Pampa
🇦🇷
Buenos Aires, Argentina
Boice-Willis Clinic
🇺🇸
Rocky Mount, North Carolina, United States
Arthritis Clinic
🇺🇸
Jackson, Tennessee, United States
OMI- Organizacion Medica de Investigacion
🇦🇷
Buenos Aires, Caba, Argentina
Royal North Shore Hospital
🇦🇺
St Leonards, Australia
Medizinische Universitaet Wien / AKH
🇦🇹
Wien, Austria
Arthritis Care and Diagnostic Center, P.A.
🇺🇸
Dallas, Texas, United States
PMG Research of Hickory
🇺🇸
Hickory, North Carolina, United States
East Penn Rheumatology Associates, PC
🇺🇸
Bethlehem, Pennsylvania, United States
Rheumatology Consultants, PLLC
🇺🇸
Knoxville, Tennessee, United States
University of North Texas Health Science Center at Fort Worth
🇺🇸
Fort Worth, Texas, United States
IMA Brasil -Instituto de Pesquisa Clinica e Medicina Avancada
🇧🇷
Sao Paulo, SP, Brazil
Sozialmedizinisches Zentrum Sued - Kaiser Franz Josef Spital
🇦🇹
Wien, Austria
UMBAL Kaspela Plovdiv
🇧🇬
Plovdiv, Bulgaria
CIP - Centro Internacional de Pesquisa
🇧🇷
Goiania, GO, Brazil
Anhui Province Hospital
🇨🇳
Hefei, China
Optimus Clinical Research Pty. Ltd.
🇦🇺
Kogarah, New South Wales, Australia
Rheuma-Ordination Favoriten
🇦🇹
Wien, Austria
The Seattle Arthritis Clinic
🇺🇸
Seattle, Washington, United States
AZ Groeninge
🇧🇪
Kortrijk, Belgium
Centre Hospitalier Universitaire de Liège
🇧🇪
Liège, Belgium
Saint Dennis Medical Group S.A.
🇦🇷
Buenos Aires, Argentina
Hospital de Clinicas de Porto Alegre
🇧🇷
Porto Alegre, RS, Brazil
The Arthritis Program Research Group Inc.
🇨🇦
Newmarket, Ontario, Canada
Revmacentrum MUDr. Mostera, s.r.o.
🇨🇿
Brno, Czechia
ARTMEDI UPD s r.o
🇨🇿
Hostivice, Czechia
Centre de Recherche Musculo-Squelettique
🇨🇦
Trois-Rivieres, Quebec, Canada
MEDIPONT Plus sro
🇨🇿
Ceske Budejovice, Czechia
Revmatologicka ambulance
🇨🇿
Praha 4, Czechia
Affidea Praha, s.r.o.
🇨🇿
Praha 11 - Chodov, Czechia
Revmatologicky ustav
🇨🇿
Praha 2, Czechia
Riesgo de Fractura S.A.
🇨🇴
Bogota D.C., Cundinamarca, Colombia
CCBR Brasil Centro de Pesquisas e Analises Clinicas Ltda
🇧🇷
Rio de Janeiro, RJ, Brazil
Manitoba Clinic
🇨🇦
Winnipeg, Manitoba, Canada
CEPIC - Centro Paulista de Investigacao Clinica e Servicos Medicos Ltda
🇧🇷
Sao Paulo, Brazil
MBAL Akta Medika OOD
🇧🇬
Sevlievo, Bulgaria
Credit Valley Rheumatology
🇨🇦
Missisauga, Ontario, Canada
Hôpital Nord
🇫🇷
Amiens, France
Office of Dr. Fernando Bianchi
🇨🇦
Hamilton, Ontario, Canada
ARTHROMED, s. r. o. Revmatologicka ambulance
🇨🇿
Pardubice, Czechia
L.K.N. Arthrocentrum, s.r.o.
🇨🇿
Hlucin, Czechia
X-MEDICA s.r.o.
🇨🇿
Brno, Czechia
J.W.-Goethe-Universitaetsklinik, Medizinische Klinik II, Abteilung fuer Rheumatologie
🇩🇪
Frankfurt am Main, Germany
Hôpital Saint-Antoine
🇫🇷
Paris, France
Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology
🇨🇳
Wuhan, Hubei, China
Peking University People's Hospital/Rheumatology and Immunology Department
🇨🇳
Beijing, China
CHR ORLEANS - Service IPROS
🇫🇷
Orleans, France
Rheumazentrum Ruhrgebiet
🇩🇪
Herne, Germany
Schlosspark-Klinik Innere Medizin II, Rheumatologie
🇩🇪
Berlin, Germany
HESTE s.r.o. Revmatologie
🇨🇿
Ceska Lipa, Czechia
Fakultni Thomayerova nemocnice s poliklinikou
🇨🇿
Praha 4, Czechia
424 General Army Hospital
🇬🇷
Thessaloniki, Greece
Seoul National University Hospital
🇰🇷
Seoul, Korea, Republic of
Daegu Catholic University Medical Center
🇰🇷
Daegu, Korea, Republic of
Privat-Praxis
🇩🇪
Aachen, Germany
Universitaetsklinik Leipzig, Klinik fur Gastroenterologie und Rheumatologie, Sektion Rheumatologie
🇩🇪
Leipzig, Germany
Asan Medical Center-University of Ulsan College of Medicine
🇰🇷
Seoul, Korea, Republic of
Charite Campus Mitte, Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie
🇩🇪
Berlin, Germany
Hopital Cochin
🇫🇷
Paris, France
Nemocnice Atlas, a.s.
🇨🇿
Zlin, Czechia
Universitaetsklinikum Wuerzburg
🇩🇪
Wuerzburg, Germany
Ambulantes Rheumazentrum Dr Soerensen
🇩🇪
Berlin, Germany
Fakultni nemocnice Hradec Kralove
🇨🇿
Hradec Kralove, Czechia
Nuselska poliklinika RTG
🇨🇿
Praha 4, Czechia
Fakultni nemocnice u sv. Anny v Brne
🇨🇿
Brno, Czechia
TAYS/Reumakeskus/Finn-Medi 1
🇫🇮
Tampere, Finland
Studienambulanz Universitaetsklinikum Erlangen Medizinische Klinik 3
🇩🇪
Erlangen, Germany
Gangnam Severance Hospital
🇰🇷
Seoul,, Korea, Republic of
Clinical Trials Unit, Timaru Hospital
🇳🇿
Timaru, New Zealand
Gangnam Severance Hospital-Yonsei University Health System
🇰🇷
Seoul, Korea, Republic of
MAV Korhaz es Rendelointezet, Reumatologiai szakrendeles
🇭🇺
Szolnok, Hungary
Mahavir Hospital & Research Center
🇮🇳
Hyderabad, Andhra Pradesh, India
Yonsei University Health System
🇰🇷
Seoul, Korea, Republic of
Hanyang University Hospital
🇰🇷
Seoul, Korea, Republic of
Dong-A University Hospital
🇰🇷
Busan, Korea, Republic of
Drug Research Center Kft
🇭🇺
Balatonfured, Hungary
General Hospital Euromedica "KYANOUS STAVROS"
🇬🇷
Thessaloniki, Greece
Waikato Hospital, Rheumatology
🇳🇿
Hamilton, New Zealand
Konkuk University Medical Center
🇰🇷
Seoul, Korea, Republic of
Eulji University Hospital
🇰🇷
Daejeon, Republic OF Korea, Korea, Republic of
Fundacion El Hospitalito
🇲🇽
Cuernavaca, Morelos, Mexico
Ponce School Of Medicine
🇵🇷
Ponce, Puerto Rico
Edificio Parra
🇵🇷
Ponce, Puerto Rico
State Educational Institution of Higher Professional Education Ural State Medical Academy of Federal
🇷🇺
Ekaterinburg, Russian Federation
GUZ Republican Hospital n.a. Baranov
🇷🇺
Petrozavodsk, Russian Federation
State Educational Institution of Higher Professional Education
🇷🇺
Ekaterinburg, Russian Federation
Seoul St. Mary's Hospital-The Catholic University of Korea
🇰🇷
Seoul, Korea, Republic of
Saint-Petersburg State Budgetary Healthcare Institution "Clinical Rheumathology Hospital #25"
🇷🇺
St. Petersburg,, Russian Federation
Unidad de Enfermedades Reumaticas y Cronico Degenerativas SC
🇲🇽
Torreon, Coahuila, Mexico
Clinical Hospital #122 named after L.G. Sokolov of the Federal Medical-Biological Agency
🇷🇺
St. Petersburg, Russian Federation
Hospital Universitari i Politecnic La Fe de Valencia
🇪🇸
Valencia, Spain
The Canterbury Geriatric Medical Research Trust, c/- The Princess Margaret Hospital
🇳🇿
Christchurch, New Zealand
Hospital Universitario Cruces
🇪🇸
Barakaldo, Vizcaya, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸
Santander, Cantabria, Spain
Rheumatology Research Institute of Russian Academy of Medical Sciences
🇷🇺
Moscow, Russian Federation
Skanes Universitetssjukhus i Malmo Reumamottagningen
🇸🇪
Malmo, Sweden
Spitalul Clinic "Sf. Maria"
🇷🇴
Bucharest, Romania
Mindful Medical Research
🇵🇷
San Juan, Puerto Rico
City Clinical Hospital # 1
🇷🇺
Novosibirsk City, Novosibirsk Region, Russian Federation
Hospital Civil. Hospital Regional Universitario Carlos Haya
🇪🇸
Malaga, Spain
NOVAPHARM s.r.o -Zeleznicna NaP, Reumatologicka ambulancia
🇸🇰
Bratislava, Slovakia
Lanssjukhuset Ryhov
🇸🇪
Jonkoping, Sweden
Complejo Hospitalario Universitario A Coruna
🇪🇸
Coruna, Spain
Norrlands Universitetssjukhus
🇸🇪
Umea, Sweden
State Healthcare Institution
🇷🇺
Ekaterinburg, Russian Federation
Hospital Nuestra Señora de Valme
🇪🇸
Sevilla, Spain
Sundsvalls Sjukhus
🇸🇪
Sundsvall, Sweden
Municipal Establishment of Health Care "Kharkiv City Clinical Hospital #8", Dept. of Rheumatology
🇺🇦
Kharkiv, Ukraine
Akademiska University Hospital
🇸🇪
Uppsala, Sweden
Hospital El Tomillar
🇪🇸
Sevilla, Spain
Reumatologicka ambulancia, REUMEX, s.r.o.
🇸🇰
Rimavska Sobota, Slovakia
Municipal City Clinical Hospital #4, Policlinic Care
🇺🇦
Lviv, Ukraine
Multifield Medical Center of Odesa National Medical University "University Clinic #1"
🇺🇦
Odesa, Ukraine
Municipal Establishment "City Hospital#7of Zaporizhzhia State Medical University
🇺🇦
Zaporizhzhia, Ukraine
Dokuz Eylul Universitesi Arastirma Uygulama Hastanesi
🇹🇷
Izmir, Turkey
Hospital Del Mar
🇪🇸
Barcelona, Spain
San Diego Arthritis Medical Clinic
🇺🇸
San Diego, California, United States
Cincinnati Rheumatic Disease Study Group, Inc.
🇺🇸
Cincinnati, Ohio, United States
Accurate Clinical Research, Inc.
🇺🇸
Houston, Texas, United States
Ege University Medical Faculty
🇹🇷
Bornova, Izmir, Turkey
St. Vincent's University Hospital
🇮🇪
Elm Park, Dublin, Ireland
Rheumatology Unit, Department of Internal Medicine, Phramongkutklao Hospital
🇹🇭
Rajathevee, Bangkok, Thailand
Goatcher Clinical Research Unit
🇦🇺
Perth, Western Australia, Australia
The Third Affiliated Hospital of Sun Yat-Sen University
🇨🇳
Guangzhou, Guangdong, China
Beijing Chaoyang Hospital, Capital University of Medical Science
🇨🇳
Beijing, Beijing, China
Xiangya Hospital of Centre-south University
🇨🇳
Changsha, Hunan, China
QiLu Hospital of Shandong University
🇨🇳
Jinan, Shandong, China
PLA General Hospital
🇨🇳
Beijing, China
Shanghai Changzheng Hospital
🇨🇳
Shanghai, Shanghai, China
Si Chuan Huaxi Hospital
🇨🇳
Chengdu, China
Rheumatology and Immunology Dept., Renji Hospital Shanghai Jiao Tong University School of Medicine
🇨🇳
Shanghai, China
Shanghai Changhai Hospital
🇨🇳
Shanghai, China
The First Affiliated Hospital of Soochow University
🇨🇳
Suzhou, China
"Department of Infectious Diseases & Immunology
🇨🇳
Tianjin, China
Frederiksberg Hospital
🇩🇰
Frederiksberg, Denmark
Falu lasarett
🇸🇪
Falun, Sweden
University of Alabama at Birmingham
🇺🇸
Birmingham, Alabama, United States
Arizona Arthritis & Rheumatology Associates, P.C.
🇺🇸
Phoenix, Arizona, United States
Oklahoma Medical Research Foundation (OMRF)
🇺🇸
Oklahoma City, Oklahoma, United States
Lynn Health Science Institute
🇺🇸
Oklahoma City, Oklahoma, United States
Vanderbilt University Medical Center
🇺🇸
Nashville, Tennessee, United States
Westroads Clinical Research, Inc.
🇺🇸
Omaha, Nebraska, United States
Heartland Clinic Research, Inc.
🇺🇸
Omaha, Nebraska, United States
Hopital Nord
🇫🇷
Amiens, France
*CHR Hopital Porte Madeleine IPROS
🇫🇷
Orleans, France
Hospital Sao Lucas da PUCRS
🇧🇷
Porto Alegre, RS, Brazil
Dr. William G. Bensen Medicine Professional Corporation
🇨🇦
Hamilton, Ontario, Canada
St Joseph's Health Centre
🇨🇦
London, Ontario, Canada
Cividino Medicine Professional Corporation
🇨🇦
Hamilton, Ontario, Canada
West Island Rheumatology Research Associates
🇨🇦
Pointe Claire, Quebec, Canada
Rheumatology and Osteoporosis Clinic
🇨🇦
Oakville, Ontario, Canada
Centre de Recherche Saint-Louis
🇨🇦
Quebec, Canada
Rheumatology Research Associates
🇨🇦
Ottawa, Ontario, Canada
Institut de Rhumatologie de Montreal
🇨🇦
Montreal, Quebec, Canada
Niagara Peninsula Arthritis Centre
🇨🇦
St. Catharines, Ontario, Canada
Hospital Universitario Virgen Macarena
🇪🇸
Sevilla, Spain
Hospital Universitario De La Paz
🇪🇸
Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸
Madrid, Spain
Federal North-West Medical Research Centre
🇷🇺
Saint-Petersburg, Russian Federation
Regional State Budget Institution Of Healthcare
🇷🇺
Tomsk, Russian Federation
Regional State Budgetary Healthcare Institution of Tomsk Regional Clinical Hospital
🇷🇺
Tomsk, Russian Federation
Krankenhaus Friedrichstadt, I. Medizinische Klinik
🇩🇪
Dresden, Germany
Schoen Klinik Hamburg-Eilbek
🇩🇪
Hamburg, Germany
Arztpraxis, Internist - Rheumatologie
🇩🇪
Nuernberg, Germany
Universitaetsklinikum Leipzig
🇩🇪
Leipzig, Germany
Klinikum der Universitaet Muenchen, Campus Innenstadt, Rheuma-Einheit
🇩🇪
Muenchen, Germany
Chonnam National University Hospital
🇰🇷
Gwangju, Korea, Republic of
Houston Institute for Clinical Research
🇺🇸
Houston, Texas, United States
Southwest Rheumatology Research, LLC
🇺🇸
Mesquite, Texas, United States
Ltd.Medical Association "Novaya Bolnitsa"
🇷🇺
Ekaterinburg, Russian Federation
Rheumatology Associates of North Alabama, PC
🇺🇸
Huntsville, Alabama, United States
Catalina Pointe Clinical Research
🇺🇸
Tucson, Arizona, United States
Radiant Research, Inc.
🇺🇸
Scottsdale, Arizona, United States
Osborne Research Center, LLC
🇺🇸
Little Rock, Arkansas, United States
Talbert Medical Group
🇺🇸
Huntington Beach, California, United States
Keck Medicine of USC
🇺🇸
Los Angeles, California, United States
University of California San Diego Center for Innovative Therapy
🇺🇸
La Jolla, California, United States
Little Rock Diagnostic Clinic, PA
🇺🇸
Little Rock, Arkansas, United States
Stanford University School of Medicine
🇺🇸
Palo Alto, California, United States
University of California Los Angeles
🇺🇸
Los Angeles, California, United States
Office of Anupama Bhat, MD
🇺🇸
Roseville, California, United States
University of Southern California (USC) Norris Comprehensive Cancer Center-
🇺🇸
Los Angeles, California, United States
Pacific Arthritis Center Medical Group
🇺🇸
Santa Maria, California, United States
Stanford Health Services - Medical Specialty Clinics
🇺🇸
Stanford, California, United States
Inland Rheumatology Clinical Trials, Inc.
🇺🇸
Upland, California, United States
Arthritis Associates and Osteoporosis Center of Colorado Springs
🇺🇸
Colorado Springs, Colorado, United States
University of Connecticut Health Center
🇺🇸
Farmington, Connecticut, United States
Boulder Medical Center, PC
🇺🇸
Boulder, Colorado, United States
Arthritis & Osteoporosis Center, PC
🇺🇸
Hamden, Connecticut, United States
Arthritis and Rheumatic Disease Specialties
🇺🇸
Aventura, Florida, United States
Delaware Arthritis and Osteoporosis Center
🇺🇸
Newark, Delaware, United States
Physicians Research Alliance LLC
🇺🇸
DeBary, Florida, United States
Southeastern Imaging and Diagnostics
🇺🇸
Gainesville, Florida, United States
Allergy, Asthma, Arthritis, & Lung
🇺🇸
Daytona Beach, Florida, United States
Jacksonville Center for Clinical Research
🇺🇸
Jacksonville, Florida, United States
Southeastern Integrated Medical PL d/b/a Florida Medical Research Institute
🇺🇸
Gainesville, Florida, United States
Florida Arthritis Center, P.L.
🇺🇸
Lake Mary, Florida, United States
Center for Arthritis and Rheumatic Diseases
🇺🇸
Miami, Florida, United States
Jeffrey Alper MD Research
🇺🇸
Naples, Florida, United States
Suncoast Clinical Research, Inc.
🇺🇸
New Port Richey, Florida, United States
Ocala Rheumatology Research Center
🇺🇸
Ocala, Florida, United States
Millennium Research
🇺🇸
Ormond Beach, Florida, United States
DMI Research, Inc.
🇺🇸
Pinellas Park, Florida, United States
Gulf Coast Medical Center
🇺🇸
Port Richey, Florida, United States
Florida Arthritis & Osteoporosis Center
🇺🇸
Port Richey, Florida, United States
Suncoast Medical Clinic
🇺🇸
Saint Petersburg, Florida, United States
Arthritis & Rheumatic Care Center
🇺🇸
South Miami, Florida, United States
St. Luke's Intermountain Research Center
🇺🇸
Boise, Idaho, United States
Institute of Arthritis Research
🇺🇸
Idaho Falls, Idaho, United States
Diagnostic Rheumatology And Research PC
🇺🇸
Indianapolis, Indiana, United States
Rockford Health Physicians
🇺🇸
Rockford, Illinois, United States
Physician's Clinic of Iowa, P.C.
🇺🇸
Cedar Rapids, Iowa, United States
Kansas City Internal Medicine
🇺🇸
Overland Park, Kansas, United States
Illinois Bone and Joint Institute, LLC
🇺🇸
Morton Grove, Illinois, United States
Springfield Clinic - Clinical Research
🇺🇸
Springfield, Illinois, United States
Bluegrass Community Research, Inc.
🇺🇸
Lexington, Kentucky, United States
Louisiana State University Health Sciences Center
🇺🇸
New Orleans, Louisiana, United States
Klein and Associates, MD, PA
🇺🇸
Cumberland, Maryland, United States
Borgess Research Institute
🇺🇸
Kalamazoo, Michigan, United States
The Arthritis Treatment Center
🇺🇸
Frederick, Maryland, United States
Bronson Internal Medicine and Rheumatology
🇺🇸
Battle Creek, Michigan, United States
Clinical Research Center of Cape Cod, Inc.
🇺🇸
Hyannis, Massachusetts, United States
QUEST Research Institiute
🇺🇸
Bingham Farms, Michigan, United States
Reliant Medical Group, Inc.
🇺🇸
Worcester, Massachusetts, United States
Reliant Medical Group, Inc. at Worcester Medical Center
🇺🇸
Worcester, Massachusetts, United States
University Physicians - Woodrail Clinic
🇺🇸
Columbia, Missouri, United States
University Of Missouri-Columbia
🇺🇸
Columbia, Missouri, United States
North Mississippi Medical Clinics, Inc.
🇺🇸
Tupelo, Mississippi, United States
Arthritis and Rheumatology Consultants, P.A.
🇺🇸
Edina, Minnesota, United States
Physician Research Collaboration, LLC
🇺🇸
Lincoln, Nebraska, United States
Clinical Pharmacology Study Group
🇺🇸
Massachusetts, Nebraska, United States
DJL Clinical Research, PLLC
🇺🇸
Charlotte, North Carolina, United States
Schwerpunktpraxis Rheumatologie
🇩🇪
Halle, Germany
Rheumatic Disease Associates, Ltd.
🇺🇸
Willow Grove, Pennsylvania, United States
Altoona Center for Clinical Research
🇺🇸
Duncansville, Pennsylvania, United States
Clinical Research Center of Reading LLP
🇺🇸
Wyomissing, Pennsylvania, United States
Austin Rheumatology Research, PA
🇺🇸
Austin, Texas, United States
Tacoma Center of Arthritis Research, PS
🇺🇸
Tacoma, Washington, United States
Seattle Rheumatology Associates
🇺🇸
Seattle, Washington, United States
Arthritis and Osteoporosis Associates, LLP
🇺🇸
Lubbock, Texas, United States
Hospital Sirio Libanes
🇦🇷
Buenos Aires, Argentina
Rheumatology Research Unit Sunshine Coast
🇦🇺
Maroochydore, Queensland, Australia
OMI - Organización Médica de Investigación
🇦🇷
Buenos Aires, Argentina
Rheumatology Research
🇦🇺
Cairns, Queensland, Australia
Centro de Estudos em Terapias Inovadoras
🇧🇷
Curitiba, PR, Brazil
Hospital Alemao Oswaldo Cruz
🇧🇷
Sao Paulo, SP, Brazil
Revmatologichen kabinet, DKTs Sveti Pantaleimon OOD
🇧🇬
Pleven, Bulgaria
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HC-FMUSP)
🇧🇷
Sao Paulo, SP, Brazil
MBAL Sveti Ivan Rilski Sofia
🇧🇬
Sofia, Bulgaria
Percuro Clinical Research Limited
🇨🇦
Victoria, British Columbia, Canada
Groupe De Recherche En Rhumatologie Et Maladies Osseuses Inc.
🇨🇦
Quebec, Canada
Arthritis Research Center, Royal University Hospital
🇨🇦
Saskatoon, Saskatchewan, Canada
Centro de Estudios Reumatologicos
🇨🇱
Santiago, RM, Chile
Hospital Base Valdivia, Policlinico de Reumatologia
🇨🇱
Valdivia, Region XIV, Chile
The Second Affiliated Hospital of Guangzhou Medical University
🇨🇳
Guangzhou, Guangdong, China
Qingdao Municipal Hospital
🇨🇳
Qingdao, Shandong, China
Xijing Hospital, The Fourth Military Medical University
🇨🇳
Xi'an, Shaanxi, China
An Hui Medical University 1st Hospital
🇨🇳
Hefei, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
🇨🇳
Hangzhou, China
Hospital Cima San Jose
🇨🇷
San Jose, Costa Rica
University Hospital Center "Zagreb"
🇭🇷
Zagreb, Croatia
Fakultni Nemocnice Brno, Interni hematoonkologicka klinika
🇨🇿
Brno, Czechia
Hospital Central de las Fuerzas Armadas
🇩🇴
Santo Domingo, Dominican Republic
PV-Medical s.r.o.
🇨🇿
Zlin, Czechia
Rheumaforschung- Studienambulanz
🇩🇪
Ratingen, Germany
Universitaetsklinikum Koeln Klinik I fuer Innere Medizin, Haus 16, 1. OG, Raum 1.008
🇩🇪
Koeln, Germany
Shirdi Sai Hospital
🇮🇳
Bangalore, Karnataka, India
Schwerpunktpraxis fuer Rheumatologie
🇩🇪
Rheine, Germany
Synexus Magyarorszag Kft.
🇭🇺
Budapest, Hungary
Shalby Hospitals
🇮🇳
Ahmedabad, Gujarat, India
Chanre Rheumatology & Immunology Center & Research
🇮🇳
Bangalore, Karnataka, India
U.O. Clinica Reumatologica
🇮🇹
Genova, Italy
Krishna Institute of Medical Sciences Ltd
🇮🇳
Secunderabad, Telangana, India
A.O.U. Careggi - SOD Medicina Interna 1 e Reumatologia
🇮🇹
Firenze, FI, Italy
Inha University Hospital
🇰🇷
Jung-gu, Incheon, Korea, Republic of
Asan Medical Center
🇰🇷
Seoul, Korea, Republic of
Subang Jaya Medical Centre
🇲🇾
Subang Jaya, Selangor, Malaysia
Hospital Angeles Mocel
🇲🇽
Mexico, D.F., Mexico
Hospital Central Dr Ignacio Morones Prieto Unidad Regional de Reumatologia y Osteoporosis
🇲🇽
San Luis Potosi, Mexico
Instituto Peruano del Hueso y la Articulacion SAC-Privado-Lima/Centro de Investigacion IPHAR
🇵🇪
Lima, Peru
De La Salle University Health Sciences Campus Clinical Epidemiology Unit
🇵🇭
Dasmarinas, Cavite, Philippines
Mary Mediatrix Medical Center
🇵🇭
Lipa City, Batangas, Philippines
NSZOZ Medicus II
🇵🇱
Cieszyn, Poland
Synexus Polska Sp. z o.o. Oddzial w Warszawie
🇵🇱
Warszawa, Poland
State Healthcare Institution Regional Clinical Hospital
🇷🇺
Barnaul, Russian Federation
"Consultative Diagnostic Rheumatology Center ""Healthy Joints"", LLC"
🇷🇺
Novosibirsk City, Novosibirsk Region, Russian Federation
State Healthcare Institution Regional Clinical Hospital for War Veterans
🇷🇺
Kemerovo, Russian Federation
Smolensk State Medical Academy
🇷🇺
Smolensk, Smolensk Region, Russian Federation
State Healthcare Institution City Hospital # 40 of Administrative Health Resort District
🇷🇺
Saint-Petersburg, Sestroretsk, Russia, Russian Federation
Russian State Medical University Moscow Faculty City Clinical Hospital #4
🇷🇺
Moscow, Russian Federation
St. Petersburg State Institution of Healthcare Consultative-diagnostic Center #85
🇷🇺
St. Petersburg, Russian Federation
Ecclesia, s.r.o Reumatologicka ambulancia
🇸🇰
Nove Zamky, Slovakia
Hospital Nuestra Senora de la Esperanza
🇪🇸
Santiago De Compostela, A Coruna, Spain
Hospital Clinico Universitario de Santiago
🇪🇸
Santiago de Compostela, A Coruna, Spain
Hospital de Basurto
🇪🇸
Bilbao, Vizcaya, Spain
Kaohsiung Veterans General Hospital
🇨🇳
Kaohsiung, Taiwan
National Cheng Kung University Hospital
🇨🇳
Tainan, Taiwan
National Taiwan University Hospital
🇨🇳
Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳
Taipei, Taiwan
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine,
🇹🇭
Amphoe Mueang, Chiang MAI, Thailand
Rheumatology Unit, Department of Internal Medicine, Rajavithi Hospital
🇹🇭
Bangkok, Thailand
"Multifield Medical Center of Odesa National Medical University ""University Clinic #1"""
🇺🇦
Odesa, Ukraine
Hacettepe University Medical Faculty
🇹🇷
Ankara, Turkey
State Institution Republican Clinical Hospital of the Ministry of Health of Ukraine
🇺🇦
Kyiv, Ukraine
State Establishment "Institute of Gerontology of NAMS of Ukraine n.a. D.F. Chebotareva"
🇺🇦
Kyiv, Ukraine
CRIMEAN Republican Institution, "Clinical Hospital n.a. M.O. Semashko"
🇺🇦
Simferopol Crimea, Ukraine
Royal Victoria Infirmary
🇬🇧
Newcastle Upon Tyne, United Kingdom
Wirral University Teaching Hospital NHS Foundation Trust-Arrowe Park Hospital
🇬🇧
Wirral, United Kingdom
The Royal Wolverhampton NHS Trust
🇬🇧
Cannock, United Kingdom
Dudley Group of Hospitals NHS Trust
🇬🇧
Dudley, WEST Midlands, United Kingdom
Southeastern Arthritis Center
🇺🇸
Gainesville, Florida, United States
Southeastern Integrated Medical, PL, d/b/a Florida Medical Research Institute
🇺🇸
Gainesville, Florida, United States
Professional Research Network of Kansas, LLC
🇺🇸
Wichita, Kansas, United States
Farmbrook Radiology Associates
🇺🇸
Southfield, Michigan, United States
Via Christi Clinic, P.A.
🇺🇸
Wichita, Kansas, United States
Dr. Jeffrey E. Poiley, MD , Office of
🇺🇸
Orlando, Florida, United States
BayCare Medical Group, Inc
🇺🇸
Tampa, Florida, United States
Sunway Medical Centre
🇲🇾
Petaling Jaya, Selangor, Malaysia
Clinic of Rheumatology Multiprofile Hospital for Active treatment Sveti Ivan Rilski
🇧🇬
Sofia, Bulgaria
Clinica Santa Maria
🇨🇱
Santiago, Chile
Estudios Clinicos V Region
🇨🇱
Vina Del Mar, V Region, Chile
University Hospital Split, Department for Internal Medicine, Division of Clinical Rheumatology
🇭🇷
Split, Croatia
Clinical Hospital "Sveti Duh"
🇭🇷
Zagreb, Croatia
Centro de Investigacion Clinica Especializada, SC
🇲🇽
Coyoacan, Mexico D.F., Mexico
Centro de Investigacion Clinica de Morelia
🇲🇽
Morelia, Michoacan, Mexico
Unidad Reumatologica Las Americas SCP
🇲🇽
Merida, Yucatan, Mexico
Southern Philippine Medical Center
🇵🇭
Davao City, Philippines
"ZDROWIE OSTEO-MEDIC" s.c. Lidia I Artur Racewicz, Agnieszka I Jerzy Supronik
🇵🇱
Bialystok, Poland
ClinicMed Badurski i wspolnicy Spolka Jawna
🇵🇱
Bialystok, Poland
Reumatologicka ambulancia, Poliklinika Ruzinov
🇸🇰
Bratislava, Slovakia
Narodny Ustav Reumatickych Chorob
🇸🇰
Piestany, Slovakia
Revita Reumatologiai Rendelo
🇭🇺
Budapest, Hungary
DKTs "Sveta Anna", Sofia / Diagnostic Consultative Center "Sveta Anna"
🇧🇬
Sofia, Bulgaria
DKTs "Sveta Anna" Sofia, Konsultativen kabinet po Revmatologia
🇧🇬
Sofia, Bulgaria
Consulta Privada Dra. Lucia Ponce
🇨🇱
Temuco, IX Region, Chile
Clinica Santa Maria, Seccion Reumatologia
🇨🇱
Providencia, Santiago, RM, Chile
Centro de Reumatologia y Ortopedia S.A.S.
🇨🇴
Barranquilla, Atlantico, Colombia
Oficina Privada Del Colegio deMedicos
🇨🇷
San Jose, Costa Rica
Hospital Putrajaya, Dept. of Medicine
🇲🇾
Putrajaya, Wilayah Persekutuan, Malaysia
Hospital Angeles del Pedregal
🇲🇽
Mexico, DF, Mexico
Centro Medico Toluca
🇲🇽
Metepec, Estado DE Mexico, Mexico
Investigacion y Biomedica de Chihuahua, SC
🇲🇽
Chihuahua, Mexico
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
🇲🇽
Mexico City, Mexico
Centrum Badan Klinicznych s.c. Wieslawa Porawska, Lukasz Porawski
🇵🇱
Poznan, Poland
Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko
🇵🇱
Sopot, Poland
Reumatologicka ambulancia, Nestatne zdravotnicke zariadenie
🇸🇰
Senica, Slovakia
Kaohsiung Medical University Chung-Ho Memorial Hospital
🇨🇳
Kaohsiung, Taiwan
Division of Allergy-Immunology-Rheumatology, Department of Medicine, Faculty of Medicine
🇹🇭
Muang District, Khonkaen, Thailand
Siriraj Hospital, Mahidol University
🇹🇭
Bangkok, Thailand
Clinic of Cardiology and Rheumatology Military Medical Academy
🇧🇬
Sofia, Bulgaria
MOBAL "D-r Stefan Cherkezov" AD,
🇧🇬
Veliko Tarnovo, Bulgaria
Centro de Diagnostico y Tratamiento Hospital San Borja Arriaran
🇨🇱
Santiago, Region Metropolitana, Chile
Centro de Investigacion en Reumatologia y Especialidades Medicas S.A.S CIREEM S.A.S
🇨🇴
Bogota, D.C., Cundinamarca, Colombia
Helsingin Reumakeskus Oy
🇫🇮
Helsinki, Finland
Chanre Rheumatology and Immunology Center and Research
🇮🇳
Bangalore, Karnataka, India
Hospital Selayang
🇲🇾
Batu Caves, Selangor, Malaysia
Centro de Investigacion del Noroeste
🇲🇽
Tijuana, BAJA California Norte, Mexico
Centro Reumatologico Queretaro
🇲🇽
Queretaro, Mexico
Angeles University Foundation Medical Center
🇵🇭
Angeles City, Pampanga, Philippines
Chong Hua Hospital
🇵🇭
Cebu City, Philippines
University of Santo Tomas Hospital
🇵🇭
Manila, Philippines
Nzoz "Nasz Lekarz"
🇵🇱
Torun, Poland
Spitalul Clinic De Recuperare
🇷🇴
Iasi, Romania
Reumatologicka ambulancia, MUDr. Zuzana Cizmarikova, s.r.o.
🇸🇰
Poprad, Slovakia
Hospital de Merida
🇪🇸
Merida, Badajoz, Spain
University Clinical Center Sarajevo
🇧🇦
Sarajevo, Bosnia and Herzegovina
Consulta Privada Dra. Marta Aliste
🇨🇱
Santiago, RM, Chile
Kiljavan Laaketutkimus Oy
🇫🇮
Hyvinkaa, Finland
St. John's Medical College and Hospital.
🇮🇳
Bangalore, Karnataka, India
Hospital Universitario Doctor Jose Eleuterio Gonzalez
🇲🇽
Monterrey, Nuevo LEON, Mexico
Hospital Nacional IV Alberto Sabogal Sologuren
🇵🇪
Callao, Peru
Centro Medico Corpac/Investigaciones en Reumatologia
🇵🇪
Lima, Peru
Szpital im. Teodora Dunina
🇵🇱
Koscian, Poland
Rheuma-Medicus - Specjalistyczne Centrum Reumatologii i Osteoporozy
🇵🇱
Warszawa, Poland
Nestatna reumatologicka ambulancia, MUDr. Pavol Polak s.r.o.
🇸🇰
Zilina, Slovakia
Dr. Alice Klinkhoff, Inc.
🇨🇦
Vancouver, British Columbia, Canada
Centro de Alta Especialidad en Reumatologia e Investigacion del Potosi, S.C.
🇲🇽
San Luis Potosi, Mexico
University of Perpetual Help Rizal Dalta Medical Center
🇵🇭
Las Piñas City, Philippines
Krakowskie Centrum Medyczne NZOZ
🇵🇱
Krakow, Poland
SYNEXUS Polska Sp. z.o.o.
🇵🇱
Wroclaw, Poland
AAGS, s.r.o. , nestatne zdravotnicke zariadenie
🇸🇰
Dunajska Streda, Slovakia
Interna a reumatologicka ambulancia
🇸🇰
Kosice, Slovakia
Chang Gung Medical Foundation-
🇨🇳
Niao Sung Hsiang, Kaohsiung County, Taiwan
Chang Gung Medical Foundation-Linkou Branch
🇨🇳
Kwei-Shan, Taoyuan County, Taiwan
Changhua Christian Hospital
🇨🇳
Changhua, Taiwan
Taichung Veterans General Hospital
🇨🇳
Taichung, Taiwan
Vinnitsa Regional Clinical Hospital n.a. Pirogov
🇺🇦
Vinnitsa, Ukraine
Crimean Republican Institution "Clinical Territorial Medical Association "University Clinic",
🇺🇦
Simferopol, Crimea, Ukraine
Office of John P. Lavery, MD, PA
🇺🇸
Allen, Texas, United States
Nexus Clinical Research
🇨🇦
St. John's, Newfoundland and Labrador, Canada
Rheumatic Diseases Clinic
🇮🇳
Ahmedabad, Gujarat, India
Hospital Tuanku Ja'afar
🇲🇾
Seremban, Negeri Sembilan, Malaysia
Springfield Clinic
🇺🇸
Springfield, Illinois, United States
Medical Associates Clinic, PC
🇺🇸
Dubuque, Iowa, United States
West Tennessee Research Institute
🇺🇸
Jackson, Tennessee, United States
Gundersen Clinic, Ltd
🇺🇸
Onalaska, Wisconsin, United States
Queen Elizabeth Hospital, Department of Rheumatology
🇦🇺
Woodville, South Australia, Australia
KW Musculoskeletal Research Inc.
🇨🇦
Kitchener, Ontario, Canada
Centro Integral en Reumatologia, SA de CV
🇲🇽
Guadalajara, Jalisco, Mexico
The Vancouver Clinic, Inc. PS
🇺🇸
Vancouver, Washington, United States
Emeritus Research
🇦🇺
Malvern East, Victoria, Australia
Sarawak General Hospital
🇲🇾
Kuching, Sarawak, Malaysia
Unidad de Investigacion en Enfermedades Cronico Degenerativas
🇲🇽
Guadalajara, Jalisco, Mexico
Clinical Research and Arthritis Centre
🇨🇦
Windsor, Ontario, Canada
Servimed S.A.S.
🇨🇴
Bucaramanga, Santander, Colombia
Rheumatology Research Associates Ltd.
🇨🇦
Edmonton, Alberta, Canada
Jiangsu Province Hospital
🇨🇳
Nanjing, China

Long-Term Effectiveness And Safety Of CP-690,550 For The Treatment Of Rheumatoid Arthritis

Recruitment & Eligibility

Study & Design

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