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Clinical Trials/NCT05819411
NCT05819411
Completed
Not Applicable

Stigma-Treatment Enhanced Incentivized Directly Observed Therapy for People With HIV Who Inject Drugs

Massachusetts General Hospital1 site in 1 country42 target enrollmentSeptember 1, 2021

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Hiv
Sponsor
Massachusetts General Hospital
Enrollment
42
Locations
1
Primary Endpoint
Feasibility of iDOT intervention
Status
Completed
Last Updated
4 months ago

Overview

Brief Summary

This study will implement a pilot randomized controlled trial (RCT, N=50) to refine and assess the feasibility and acceptability of an emotion regulation and communication skills intervention designed to improve engagement in HIV-care among HIV+ people who report opioid and/or stimulant use and are sub-optimally engaged in HIV care.

Detailed Description

Eligible study participants will be screened and enrolled at Fenway Health (Boston, MA). All participants will receive substance use treatment referral information if interested. Participants will be randomized to one of two treatment arms. Participants in both arms will receive a mobile application-facilitated incentivized directly observed therapy (iDOT) intervention. Participants in the control arm will receive iDOT alone. Participants in the intervention arm will receive iDOT in combination with the iSTRIVE intervention. After randomization, participants in the iSTRIVE intervention group will be offered 6 therapy sessions focused on behavioral strategies for improving HIV self-care, meta-cognitive awareness of emotions and thoughts, cognitive restructuring, and assertive communication skills. Participants in the iSTRIVE intervention arm will also receive messages containing customized compassionate self-statements to enhance HIV-related self-care. All participants will be compensated for every research visit and adherence to the iDOT protocol.

Registry
clinicaltrials.gov
Start Date
September 1, 2021
End Date
July 31, 2025
Last Updated
4 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Abigail Batchelder, Ph.D., M.P.H.

Associate Professor

Massachusetts General Hospital

Eligibility Criteria

Inclusion Criteria

  • HIV positive
  • HIV virally unsuppressed (\>20 copies/mL) in past year or no past-year HIV viral load result
  • Opioid and/or stimulant use behavior endorsed in past 6 months
  • Able to provide informed consent
  • 18 years or older
  • English speaking

Exclusion Criteria

  • HIV negative
  • Denying drug use in past 6 months

Outcomes

Primary Outcomes

Feasibility of iDOT intervention

Time Frame: change from baseline to 12 weeks after intervention completion

Percent of DOT video check ins completed by participants (≥50% considered indicative of feasibility).

Feasibility of iSTRIVE intervention

Time Frame: change from baseline to 12 weeks after intervention completion

Percent of sessions completed (≥70% considered indicative of feasibility).

Acceptability of intervention

Time Frame: 12 weeks after intervention completion

A qualitative analysis of exit interviews conducted with iSTRIVE study intervention participants.

Secondary Outcomes

  • HIV Viral Load(change from baseline to 12 weeks after intervention completion)
  • Substance Use(change from baseline to 12 weeks after intervention completion)
  • Injection Drug Use Behaviors(change from baseline to 12 weeks after intervention completion)

Study Sites (1)

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