Association Between Irisin, Inflammatory Markers and Metabolic Status in Obese Children With Type 2 Diabetes Mellitus
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Correlation of irisin levels and anthropometric parameters in healthy control children
研究概览
简要总结
The objective of this study was to investigate the association of irisin with inflammatory markers as well with metabolic and anthropometric parameters in children and adolescents with type 2 diabetes mellitus compared with healthy controls.
详细描述
Mexican children and adolescents previously diagnosed with type 2 diabetes mellitus according to the American Diabetes Association (ADA) criteria were recruited and compared to healthy controls.
The participants will undergo:
- vital signs measurement (systolic and diastolic blood pressure, heart rate, respiratory rate)
- anthropometric variables measurement (BMI, weight, waist circumference, hip circumference, body fat %)
- laboratory studies: glucose, triglycerides, HDL-c, C reactive protein, irisin
After statistical analyses the investigators will compare the relationship of irisin and the inflammatory profile and the anthropometric parameters of diabetic patients versus lean controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Have been previously diagnosed with T2DM according to the American Diabetes Association (ADA) criteria .
- •Healthy controls were required to have:
- •Normal weight according to the Centers for Disease Control and Prevention (CDC) criteria.
- •No metabolic abnormalities on blood samples
- •No previously diagnosed cardiometabolic diseases
- •Not been using antihypertensive, lipid or glucose lowering medications
排除标准
- •Disapproval by the children's physician due to any at-risk medical condition known by the parents
- •Use of drugs for high blood pressure, hyperglycemia, or dyslipidemia
结局指标
主要结局
Correlation of irisin levels and anthropometric parameters in healthy control children
时间窗: 1 day
Correlation of irisin levels and anthropometric parameters in healthy control children
Correlation of irisin levels and anthropometric parameters in children with type 2 diabetes mellitus (T2DM)
时间窗: 1 day
Correlation of irisin levels and anthropometric parameters in children with T2DM
Correlation of irisin levels and cytokines levels in children with T2DM
时间窗: 1 day
Correlation of irisin levels and cytokines levels in children with T2DM
Comparison between groups
时间窗: 1 day
Compare the correlations of irisin woth anthropometric parameters and INFLAMMATORY MARKERSbetween children diagnosed with T2DM and healthy controls
Correlation of irisin levels and C reactive protein levels in healthy control children
时间窗: 1 day
Correlation of irisin levels and C reactive protein levels in healthy control children
次要结局
未报告次要终点
研究者
Leticia Elizondo-Montemayor
Dean of the Clinical Nutrition and Obesity Research Center. School of Medicine TEC Salud. Tecnológico de Monterrey
Instituto Tecnologico y de Estudios Superiores de Monterey