Endogenous Lithium Clearance in Acute Kidney Injury

Recruiting

• Conditions: Acute Kidney Injury Due to Sepsis; Proximal Tubule Function; Lithium Clearance
• Interventions: Diagnostic Test: Lithium clearance

• Registration Number: NCT05982340
• Lead Sponsor: University Hospital of North Norway

Brief Summary

Critically ill patients are at high risk of developing acute kidney injury (AKI). Lithium is freely filtrated at the glomerulus and almost completely reabsorbed in the proximal tubule, which provides a quantitative estimation of proximal tubule reabsorption. The investigators hypothesized that endogenous lithium reabsorption is impaired in the early stages of critical illness.

Investigators would like to study 10 ICU patients with AKI diagnosed, 10 patients without AKI, and 10 healthy controls.

Detailed Description

Blood and urine samples will be obtained at 08:00, 14:00 and 20:00 during one day. Renal clearance of creatinine (CCr) and lithium will be calculated.

Study Timeline

• Study First Submitted: 2023-07-31
• Study First Submitted QC: 2023-07-31
• Study Start: 2023-08-01
• Study First Posted: 2023-08-08
• Status Verified: 2024-02
• Last Update Submitted: 2025-02-24
• Last Update Posted: 2025-02-27
• Primary Completion: 2025-05-30
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• ICU patients diagnosed with AKI, without AKI and healthy controls

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group 1	Lithium clearance	ICU patients with AKI
Group 3	Lithium clearance	Healthy controls
Group 2	Lithium clearance	ICU patients with normal renal function

Primary Outcome Measures

Name	Time	Method
Renal lithium clearance	2 days	Clearance of lithium from the body

Trial Locations

Locations (1)

University Hospital of North Norway; 🇳🇴 Tromsø, Troms, Norway