Filter Life In Renal Replacement Therapy

Phase 3

Recruiting

• Conditions: Acute Kidney Injury; Renal Replacement Therapy; Renal and Urogenital - Kidney disease

• Registration Number: ACTRN12612000765820
• Lead Sponsor: Dr. Matthew Brain

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-07-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Greater than 18 years old
Diagnosis of acute renal failure with an indication for renal replacement therapy as assessed by one or more of the following criteria:Oliguria (urine output < 100ml in a 6hour period) unresponsive to fluid resuscitation;volume overload, not correctable by diuretics in spite of adequate blood pressure and creatinine > 100umol.L; increase of serum creatinine > 300 umol/L or BUN > 25mmol/L;increase of serum potassium > 6.5 mmol/L due to AKI

Exclusion Criteria

Patient weight < 30kg (determined by machine specification)

Inability to enter randomization due to a contraindication to one of the treatment arms:

Indication for systemic anticoagulation with heparin (therapeutic range APTT) or an equivalent therapeutic dose of low molecular weight heparin (note this does not include routine thromboprophylaxis with these agents)

Prior development of HIT

History of anaphylaxis to heparin, protamine or citrate.

Pregnancy, or lactation.

Patients on chronic renal replacement therapy prior to ICU presentation.

Indication for therapeutic hypothermia

Previous participation in the same study

Indication for a filter set other than the AN69 ST100 1m2 set or a specific dialysis prescription differing from the study protocol (as deemed by the treating physician)

Study & Design

• Study Type: Interventional
• Study Design: Not specified