Method Development and Assessment of the Effects of Tobacco Products on Oral Cavity Cells
- Conditions
- Squamous Cell Carcinoma
- Registration Number
- NCT01484769
- Lead Sponsor
- University of Louisville
- Brief Summary
Collection of tissues for analysis from patients undergoing elective neck dissection.
The hypothesis of the study is that specific genetic alterations occur in head and neck cancers that have spread to regional and/or distant sites, and these alterations can be identified from biopsy specimens to allow more accurate staging of tumor and better treatment planning.
- Detailed Description
The standard of care for the treatment of most squamous cell carcinoma of the head and neck is surgical extirpation of the primary tumor and elective neck dissection to remove regional nodes at risk for spread. Via this treatment regimen, the investigators will be able to prospectively obtain tissues for analysis from patients undergoing elective neck dissection.
The specific aims of this study are to compare gene expression between head and neck tumors with and without regional lymph node metastases, and to compare gene expression between head and neck tumor with and without distant metastases.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- All patients with biochemical evidence of squamous cell carcinoma of the head and neck.
- Patients without biomedical evidence of squamous cell carcinoma.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (3)
Kosair Children's Hospital
🇺🇸Louisville, Kentucky, United States
Norton Hospital
🇺🇸Louisville, Kentucky, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States