Evaluation of Pediatric Measles Cases in 2019: Single-Center Experience

Completed

• Conditions: Measles

• Registration Number: NCT05614791
• Lead Sponsor: Marmara University

Brief Summary

Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease.

The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.

Detailed Description

Measles, can be prevented and eliminated by vaccination, is a highly contagious viral disease that can lead to serious complications, disability, and death. As a result of the World Health Organization (WHO) and United Nations International Children's Emergency Fund (UNICEF) strategic plans, the annual global incidence of measles decreased by 75% over the period 2000-2015, and the estimated global mortality rate fell by 73%. For the current 2019 period, the European and the Eastern Mediterranean Region has recorded respectively more than two-fold and 1.5-fold increase in reported measles cases. As it is known, no specific antiviral treatment exists for the measles virus therefore, vaccination is still the most effective method of preventing disease.

The aim of this study was to evaluate the measles cases in districts where the refugees live quite intensely.

This retrospective study was consecutively enrolled children who were considered as suspicious measles case according to with clinical features and attended in Esenler Gynecology and Pediatrics Hospital Pediatric Clinic between 01 January-30 June 2019.

Study Timeline

• Study Start: 2019-01-01
• Primary Completion: 2019-06-30
• Study Completion: 2020-05-30
• Status Verified: 2022-11
• Study First Submitted: 2022-11-06
• Study First Submitted QC: 2022-11-06
• Study First Posted: 2022-11-14
• Last Update Submitted: 2024-11-19
• Last Update Posted: 2024-11-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• The suspicious case of measles
• Measles/Rubella Case Notification and Laboratory request and result form and Measles/ Rubella Case Study form must be filled
• Accept the informed consent form
• Positive Measles Ig M and Measles Ig G laboratory test

Exclusion Criteria

• Rejected the informed consent form

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluate the effect of measles vaccination status on symptom duration	baseline	compare the groups symptom durations (day) who fully, partly or not vaccinated
Evaluate the effect of vitamin A treatment on symptom duration	in the first month after the first symptom observed	compare the groups symptom durations (day) who get or not get vitamin A treatment

Secondary Outcome Measures

Name	Time	Method
Evaluate the effect of vitamin A treatment on leucocyte count	baseline	compare the groups leucocyte count who get or not get vitamin A treatment
Evaluate the effect of measles vaccination status on leucocyte count	baseline	compare the groups leucocyte count who fully, partly or not vaccinated

Trial Locations

Locations (2)

Haseki Training and Research Hospital; 🇹🇷 Istanbul, Turkey

Esenler Maternity and Child Health Hospital; 🇹🇷 Istanbul, Esenler, Turkey