Effectiveness of Measles Vaccine in Health Care Professionals During COVID-19 Outbreak (Randomized Controlled Trial)
试验速览
- 阶段
- 3 期
- 状态
- 暂停
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- COVID-19 disease incidence
研究概览
简要总结
Till now, mortality reports among children below 9 years remains extremely low despite that the incidence of death toll is high and exceeding 50,000 patients among older population, One speculation for lower SARS infectivity is that cross-protective antibodies against measles vaccine ( MV). In mice susceptible to measles virus, recombinant MV induced the highest titers of neutralizing antibodies and fully protected immunized animals from intranasal infectious challenge with SARS-CoV,
The primary objective of the present study is to determine the benefit of measles vaccine in health care professional to decrease the incidence of COVID-19.
We Hypothesized that, measles vaccine may lower the incidence of serologically proven SARS-CoV-2 infection and reported respiratory illness
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-50 years old
- •Subjects who are willing to comply with the requirements of the study protocol and scheduled visits (for example, completion of the subject diary, return for follow-up visits) and who are willing to make themselves available for the duration of the study with access to a consistent means of telephone contact
排除标准
- •acute severe illness
- •recent receipt of a blood product
- •history of thrombocytopenia
- •Pregnant females
- •any chronic medical condition
- •Any participant receiving any immune suppressive medication
- •Immunocompromised staff
- •Participants who have egg allergy
- •Participants who care for immune compromised hosts
- •Participants who test positive for COVID-19 serology prior to randomization
研究组 & 干预措施
MMR vaccine
0.5 ml subcutaneous of MMR vaccine will be injected in posterior triceps aspect of upper arm
干预措施: Measles-Mumps-Rubella Vaccine (Drug)
Control
0.5 ml subcutaneous of saline will be injected in posterior triceps aspect of upper arm
干预措施: Placebos (Drug)
结局指标
主要结局
COVID-19 disease incidence
时间窗: Time Frame: Measured over the 6 months following randomization
Number of participants with asymptomatic or mild COVID-19 disease defined as fever (using self-reported questionnaire), plus at least one sign or symptom of respiratory disease including cough, runny/blocked nose (using self-reported questionnaire), plus positive SARS-Cov-2 test (PCR or serology)
次要结局
- SARS-CoV-2 pneumonia(Time Frame: Measured over the 6 months following randomization)
- Critical care admission duration with SARS-CoV-2(Time Frame: Measured over the 6 months following randomization)
- Oxygen therapy with SARS-CoV-2(Time Frame: Measured over the 6 months following randomization)
研究者
Ahmed Mukhtar
professor of anesthesia and intensive care
Kasr El Aini Hospital