Salt Intake and Lactobacillus Abundance

Not Applicable

Completed

• Conditions: Healthy Volunteers; Sodium; Probiotics
• Interventions: Dietary Supplement: Probiotics; Dietary Supplement: Salt

• Registration Number: NCT02971787
• Lead Sponsor: Charite University, Berlin, Germany

Brief Summary

To investigate the influence of an increased salt intake (6 g/d for 14 days) on the relative abundance of gut lactobillus species in healthy men

Detailed Description

Not available

Study Timeline

• Study Start: 2016-11
• Study First Submitted: 2016-11-18
• Study First Submitted QC: 2016-11-21
• Study First Posted: 2016-11-23
• Primary Completion: 2017-06
• Study Completion: 2017-06
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-07
• Last Update Posted: 2022-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

• Healthy men
• 18 - 50 years
• Body mass index 18,5 - 29,9 kg/m2

Exclusion Criteria

• Clinically relevant heart, lung, liver, and kidney disease
• Current or chronic infections
• Habitual intake of probiotics or dietary supplements

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Probiotics and salt	Salt	Lactobacillus enrichment and salt increase
Probiotics and salt	Probiotics	Lactobacillus enrichment and salt increase

Primary Outcome Measures

Name	Time	Method
Decrease of relative abundance of four lactobacillus species	14 days

Secondary Outcome Measures

Name	Time	Method
Increase of systolic blood pressure	14 days
Increase of pulse wave velocity	14 days
Increase of lymphocytic pro-inflammatory mediators	14 days

Trial Locations

Locations (1)

Experimental and Clinical Research Center; 🇩🇪 Berlin, Germany