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Clinical Trials/NCT02971787
NCT02971787CompletedNot Applicable

Influence of Increased Salt Intake on Lactobacillus Abundance in Healthy Men

Charite University, Berlin, Germany2 sites in 1 country8 target enrollmentStarted: November 2016Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
8
Locations
2
Primary Endpoint
Decrease of relative abundance of four lactobacillus species
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

To investigate the influence of an increased salt intake (6 g/d for 14 days) on the relative abundance of gut lactobillus species in healthy men

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Basic Science
Masking
None

Eligibility Criteria

Ages
18 Years to 50 Years (Adult)
Sex
Male
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Healthy men
  • •18 - 50 years
  • •Body mass index 18,5 - 29,9 kg/m2

Exclusion Criteria

  • •Clinically relevant heart, lung, liver, and kidney disease
  • •Current or chronic infections
  • •Habitual intake of probiotics or dietary supplements

Outcomes

Primary Outcomes

Decrease of relative abundance of four lactobacillus species

Time Frame: 14 days

Secondary Outcomes

  • Increase of systolic blood pressure(14 days)
  • Increase of pulse wave velocity(14 days)
  • Increase of lymphocytic pro-inflammatory mediators(14 days)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Anja Maehler

Principle Investigator

Charite University, Berlin, Germany

Study Sites (2)

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