Fermented Grape Combined With Fruits and Vegetables Drink on Anti-aging and Anti-inflammatory

Not Applicable

Completed

• Conditions: Skin Condition
• Interventions: Dietary Supplement: fermented grape drinks; Dietary Supplement: placebo group

• Registration Number: NCT04805697
• Lead Sponsor: TCI Co., Ltd.

Brief Summary

60 subjects were recruited and divided into placebo group and fermented grape drinks group.

Detailed Description

In this study, using a fermented grape drinks made of fermented grapes with fruit and vegetable powder to explore whether it can improve the skin's condition and achieve anti-inflammatory effects. Sixty subjects were recruited and divided into placebo group and fermented grape drinks group. After drinking for 8 weeks, skin test and blood biochemical analysis were performed.

Study Timeline

• Study Start: 2019-10-01
• Primary Completion: 2020-08-31
• Study Completion: 2020-10-31
• Status Verified: 2021-03
• Study First Submitted: 2021-03-16
• Study First Submitted QC: 2021-03-16
• Last Update Submitted: 2021-03-17
• Study First Posted: 2021-03-18
• Last Update Posted: 2021-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Dry skin.
2. Rough skin
3. Large pores
4. Dark yellow complexion
5. Sagging skin

Exclusion Criteria

1. Skin disorders
2. Liver diseases
3. Kidney diseases
4. Allergy to cosmetics, drugs, or foods
5. Pregnant and lactating women
6. People who had any cosmetic procedures before 4 weeks of the study
7. Area of facial spot over 3 cm2
8. Vegan
9. People who took collagen supplements in the past 3 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
fermented grape drinks	fermented grape drinks	subjects drank 50 ml , 1 bottle a day for 8 week
placebo group	placebo group	subjects drank 50 ml , 1 bottle a day for 8 week

Primary Outcome Measures

Name	Time	Method
skin moisture	8 week	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using probe system GL2000 \& MPA10 to examine skin moisture (The higher the value, the higher the gloss, no unit)
skin spot	8 week	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then usig VISIA-CR to examine skin spot (The higher the value, the larger the pore area, mm2)
skin brightness	8 week	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using corneometer CM825 to examine skin brightness (The higher the value, the more water content, C.U., corneometer units )
inflammatory cytokines	8 week	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using ELISA kit to examine inflammatory cytokines (pg/ml)
skin elasticity	8 week	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using cutometer dual MPA580 to examine skin elasticity (The closer the R2 value is to 1, the better the elasticity and no unit)
skin wrinkle	8 week	The subjects divided into a placebo group (n=30) and an experimental group (n=30). Each subject was informed to consume one bottle of a 50 mL of grape drink or a placebo drink daily for 8 weeks, then using VISIOSCAN-VC20 to examine skin wrinkle (The higher the value, the more wrinkles, surface evaluation of wrinkles, SEW)

Trial Locations

Locations (1)

Research & Design Center, TCI CO., Ltd; 🇨🇳 Taipei, Taiwan