Evaluation of Different Orthodontic Tooth Movements Assisted With Injectable Platelet Rich Fibrin

Phase 1

• Conditions: Effect of Platelet Rich Fibrin With Different Tooth Movements
• Interventions: Biological: injectable platelet rich fibrin

• Registration Number: NCT05616936
• Lead Sponsor: Al-Azhar University

Brief Summary

The present prospective clinical study will be undertaken for assessment of the effect of application of i-PRF on the rate of levelling and alignment, molar distalization\& intrusion of anterior teeth in deep bite cases

Detailed Description

Assessment of the effect of application of i-PRF on the rate of levelling and alignment, molar distalization\& intrusion of anterior teeth in deep bite cases

Study Timeline

• Status Verified: 2022-11
• Study First Submitted: 2022-11-09
• Study First Submitted QC: 2022-11-09
• Last Update Submitted: 2022-11-09
• Study First Posted: 2022-11-15
• Last Update Posted: 2022-11-15
• Study Start: 2023-01-01
• Primary Completion: 2023-04-01
• Study Completion: 2023-04-01

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

An age range from 15-22 years. Severe crowding or protrusion requiring 1st premolars extractions followed by symmetrical canine retraction.

All permanent teeth present, 3rd molars are excluded. Good oral and general health. No systemic disease/medication that could interfere with orthodontic tooth movement. No previous orthodontic treatment.

Exclusion Criteria

Patient diagnosed to have an indication for non-extraction approach.

Poor oral hygiene or periodontally compromised patient. Patient with craniofacial anomalies or previous history of trauma, bruxism or parafunctions.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group I	injectable platelet rich fibrin	Intervention side: application of i-PRF with distalization of maxillary first molar that will be performed on intervention sides according to a standardized protocol.
Group A	injectable platelet rich fibrin	levelling and alignment assisted with Injectable Platelet-rich fibrin (i-PRF) according to a standardized protocol.
Group a	injectable platelet rich fibrin	Will includes 9 patients who will receive intrusive arch after leveling and alignment assisted Injectable Platelet-rich fibrin (i-PRF) according to a standardized protocol.

Primary Outcome Measures

Name	Time	Method
effect of injectable platelet rich fibrin on different tooth movements	post interventional at 4 months	rate of tooth movement

Trial Locations

Locations (1)

AlAzhar university; 🇪🇬 Cairo, Egypt