Assessment of Different Orthodontic Tooth Movements Assisted With Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin

Phase 1

• Conditions: Injectable Plasma-rich Fibrin Versus Low-Level Laser Therapy on Othodontic Movement
• Interventions: Combination Product: Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin

• Registration Number: NCT05966987
• Lead Sponsor: Al-Azhar University

Brief Summary

The present prospective clinical study will be undertaken for assessment of the effect of application of Injectable plasma-rich fibrin versus Low-Level Laser Therapy onthe rate of different orthodontic tooth movements,

Detailed Description

The present prospective clinical study will be undertaken for assessment of the effect of application of Inject able plasma-rich fibrin versus Low-Level Laser Therapy on the rate of different orthodontic tooth movements, namely: canine retraction, mandibular incisors leveling and alignment, maxillary molar distalization and maxillary incisor intrusion.

Study Timeline

• Status Verified: 2023-07
• Study First Submitted: 2023-07-20
• Study First Submitted QC: 2023-07-28
• Last Update Submitted: 2023-07-28
• Study Start: 2023-08
• Study First Posted: 2023-08-01
• Last Update Posted: 2023-08-01
• Primary Completion: 2024-02
• Study Completion: 2024-09

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

A- leveling and alignment Eligibility criteria

1. Complete permanent dentition (third molars not included).

2. Moderate mandibular anterior crowding (with Little's irregularity index score greater than 4 mm) who required nonextraction approach in the mandibular arch.

3. No tooth size, shape or root abnormalities visible on patient's radiographic records.

4. No spaces in the mandibular arch.

5. No blocked out tooth that did not allow for placement of the bracket at the initial bonding appointment.

6. No required management with interproximal stripping, intermaxillary elastics, open NiTi springs, and removable or extra-oral devices. Maxillary molar distalization Inclusion criteria:

7. Age ranges from 14 to 17 years. 2. Bilateral Class II molar relationship. 3. Skeletal Class I or mild Class II relationship. 4. Normal or decreased vertical height. 5. No posterior crowding or spaces. 6. Fully erupted maxillary first and second molars. 7. Congenitally missing or extracted third molars. 8. Good oral hygiene. 9. Absence of any periodontal disease and alveolar bone loss. 10. Absence of medications that may inhibit orthodontic movement

• Lower incisor leveling and alignment Inclusion criteria

  1. Complete permanent dentition (third molars not included);
  2. Moderate mandibular anterior crowding (with little's irregularity index score greater than 4 mm) who required non-extraction approach in the mandibular arch;
  3. No tooth size, shape or root abnormalities visible on the patient's radiographic records;
  4. No spaces in the mandibular arch;
  5. No blocked out tooth that did not allow for placement of the bracket at the

initial bonding appointment; 6. No required management with interproximal stripping, inter-maxillary elastics, open NiTi springs, and removable or extra-oral devices. Canine retraction Eligibility criteria

1. Age, 15 to 25 years;
2. Class ii division 1 malocclusion with mild or no crowding;
3. No previous orthodontic treatment;
4. No systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency;
5. Adequate oral hygiene;
6. Probing depth values not exceeding 3 mm across the
7. Entire dentition;
8. Adequate thickness of the attached gingiva (1-2 mm);
9. No radiographic evidence of bone loss

Exclusion Criteria

Exclusion criteria:

1. Patients who required surgery to correct skeletal discrepancies.
2. Patients with congenital dentoskeletal disorders.
3. Missed or mutilated teeth in maxillary arch.
4. Patients with poor oral hygiene and/or periodontally compromised patients Severe dental crowding that necessitates an extraction approach 2. Abnormal anteroposterior and vertical relationships; 3. Patients with cleft lip and palate, anomalies, and syndromes; 4. Previous orthodontic 5. Treatment; 6. Regular medications intake that could interfere with otm. -

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
i-PRF side: canine retraction	Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin	application of i-PRF with translation of maxillary canine that will be performed on intervention sides according to a standardized protocol
LLLT group: Intrusion	Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin	intrusion assisted with application of LLLT according to a standardized protocol
LLLT side canine retraction	Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin	translation of maxillary canine that will be performed with LLLT application according to a standardized protocol
i-PRF group: leveling and alignment	Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin	leveling and alignment assisted with Injectable platelet-rich fibrin (i-PRF) according to a standardized protocol
LLLT group: leveling and alignment	Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin	leveling and alignment be commenced with application of LLLT according to a standardized protocol
I-PRF group: Intrusion	Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin	intrusion assisted with Injectable platelet-rich fibrin (i-PRF) according to a standardized protocol
I-PRF groupMolar distalization group inrervention side	Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin	Idistalization assisted with Injectable platelet-rich fibrin (i-PRF) according to a standardized protocol
LLLT group: distalization intervntion side	Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin	distalization will be commenced with application of LLLT according to a standardized protocol

Primary Outcome Measures

Name	Time	Method
assessment of the effect of application of Injectable plasma-rich fibrin versus Low-Level Laser Therapy on the accelration rate of different orthodontic tooth movements by millimeter	6 months

Trial Locations

Locations (1)

AlAzhar university; 🇪🇬 Cairo, Egypt