Comparison of Efficacy At Steady State of Antihistamines : Levocetrizine, Fexofenadine and Desloratadine On skin test responses to histamine and allergens Responses -a randomised-placebo controlled study
- Conditions
- Allergy,allergic rhinitisallergic rhinitis,antihistamine,skin test,histamine,allergen,levocetirizine,fexofenadine,deloratadine
- Registration Number
- TCTR20150207001
- Lead Sponsor
- Faculty of Medicine, Chulalongkorn University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 20
(1) male or female who is 15-65 years old,
(2) documented diagnosis of allergic rhinitis with remarkably positive skin prick test (as defined by mean diameter was at least 5 mm. with/without pseudopod) for house dust mite or American cockroach,
(3) no concomitant drug used,
(4) no steroid or its derivatives intake at least 4 weeks prior to the study,
(5) never undergone immunotherapy and
(6) understand and agree with all steps in the study.
(1) having other concomitant medical conditions except for mild severity of atopic diseases,
(2) pregnant or breastfeeding,
(3) having the history of anaphylaxis or severe allergic response to skin prick test with house dust mite or cockroach, (
4) dependent on antihistamine and cannot stop using it due to exacerbation of disease and
(5) history of severe allergic response to levocetrizine, fexofenadine or desloratadine.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method allergen-induced skin wheal and flare at 7 days of the treatment size in millimetre of the wheal and flare diameters
- Secondary Outcome Measures
Name Time Method histamine-induced skin wheal and flare at 7 days of the treatment size in millimetre of the wheal and flare diameters,nasal symptoms at 7 days of the treatment total nasal symtom score