Evaluation of the effect of curcumin in the prevention of vancomycin-induced nephrotoxicity in patients hospitalized in the intensive care unit of Kosar Hospital, Semnan: a randomized, double-blinded, placebo-controlled clinical trial

Phase 3

• Conditions: Acute kidney failure.; Acute kidney failure, unspecified; N17.9

• Registration Number: IRCT20240501061620N1
• Lead Sponsor: Semnan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Patients aged 18-65, receiving vancomycin
Creatinine clearance > 45 ml/min

Exclusion Criteria

Proteinuria and/or hematuria, acute kidney injury or any underlying renal disorder
Sepsis
Sever liver disease
Sever and active bleeding
Receiving any other nephrotoxic drug
Receiving anticoagulant drugs at therapeutic doses or receiving warfarin
Receiving antioxidant supplements

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum Creatinine. Timepoint: At baseline and 2, 4, 6, and 8 days after initiation of intervention. Method of measurement: Spectrophotometry.;Blood Urea Nitrogen. Timepoint: At baseline and 2, 4, 6, and 8 days after initiation of intervention. Method of measurement: Spectrophotometry.;Creatinine Clearance. Timepoint: At baseline and 2, 4, 6, and 8 days after initiation of intervention. Method of measurement: Modification of Diet in Renal Disease (MDRD) Formula.;24-hour Urine Output. Timepoint: Days 1 to 7. Method of measurement: Urine bag.;The number of patients with acute kidney injury. Timepoint: End of intervention. Method of measurement: Counting.;Sequential Organ Failure Assessment (SOFA). Timepoint: At baseline and end of intervention. Method of measurement: SOFA table.

Secondary Outcome Measures

Name	Time	Method
Mortality rate of patients. Timepoint: After intervention until discharge from ICU. Method of measurement: Counting.;Length of stay in the ICU. Timepoint: At discharge day from ICU. Method of measurement: Counting.