Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

Completed

• Conditions: Fitness; Aging; Physical Functioning; Cognitive Functioning
• Interventions: Genetic: Biomarker studies

• Registration Number: NCT01720472
• Lead Sponsor: Duke University

Brief Summary

The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in order to develop a diverse cohort with specific physical and cognitive performance data paired with biological samples.

Detailed Description

The MURDOCK Study, proposes this Horizon 2 study to collect a brief physical and cognitive performance assessment from 1,000 MURDOCK Registry participants. Blood sample aliquots will also be obtained. These physical and cognitive performance data, paired with -omics data from plasma and serum sample analyses, offer promise in the discovery of biomarkers for functional decline. This research will provide an important basis for our understanding of the physical, lifestyle, and genetic factors which, over the lifespan, contribute to changes in physical and cognitive capabilities as we age.

Study Timeline

• Study Start: 2012-05
• Study First Submitted: 2012-10-31
• Study First Submitted QC: 2012-10-31
• Study First Posted: 2012-11-02
• Primary Completion: 2018-08-28
• Study Completion: 2018-08-28
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-30
• Last Update Posted: 2019-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina for 6 or more months of the year.
• Age 30 or older

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Exclusion Criteria

• Female that is currently pregnant
• Having had a heart attack, angina, congestive heart failure, or fluid in the lungs within the past 6 months
• Participant that requires consent by a legally authorized representative
• Participant that cannot walk 30ft without human assistance

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Community, Physical Performance	Biomarker studies	-

Primary Outcome Measures

Name	Time	Method
Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository	Upto 2 years or 24 months	Factors associated with physical function and physical activity and change in physical activity and function over two-year follow-up.

Trial Locations

Locations (6)

Bethesda Health Center; 🇺🇸 Charlotte, North Carolina, United States

McGill Family Medicine; 🇺🇸 Concord, North Carolina, United States

Carolinas Medical Center NorthEast Medical Arts Building; 🇺🇸 Concord, North Carolina, United States

Lake Norman Community Health Clinic; 🇺🇸 Huntersville, North Carolina, United States

Ada Jenkins Center; 🇺🇸 Davidson, North Carolina, United States

Harrisburg Sleep Center; 🇺🇸 Harrisburg, North Carolina, United States