Evaluation of the therapeutic effect of integrated traditional Chinese and western medicine on macular edema of central retinal vein occlusio

Phase 1

• Conditions: Retinal vein occlusion-macular edema

• Registration Number: ITMCTR2022000018
• Lead Sponsor: Eye hospital of Chinese Academy of Chinese Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

(1) Age: 30 and 75 years old;
(2) Meet the diagnostic criteria for western medicine diagnosis of macular edema of central retinal vein obstruction in the diagnostic criteria and the diagnostic criteria of sputum and blood stasis syndrome syndrome;
(3) Patients who voluntarily participate in the project study and have good compliance.

Exclusion Criteria

(1) Combined with keratitis, endophthalmitis and other active bacteria, viruses, fungal infections;
(2) With macular hole, central serous chororetinopathy, diabetic retinopathy, retinopathy, retinal pigmentosa, and other fundus diseases affecting retinal detachment;
(3) Combined with the refractive interstitial turbidity, and unable to complete the FFA or OCT inspection;
(4) Whole-body or eye conditions are not suitable for room water extraction and testing;
(5) Allergic to leezumab, fluorescein sodium contrast agent, or allergic to the components of the formula;
(6) Suffering from serious heart, brain, liver, kidney, blood system and other systemic diseases;
(7) With neurological and mental disorders, unable to cooperate or unwilling to cooperate;
(8) Pregnant or lactating women or those with recent family plans;
(9) Those who have participated in other clinical trials 3 months before selection, or other circumstances that the investigator considers unsuitable to participate in this trial.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Macular foveal thickness;

Secondary Outcome Measures

Name	Time	Method
Detection of blood flow density and optic disc blood flow in the macular area;Best-corrected visual acuity examination;Metabolomics examination of aqueous humor;Traditional Chinese medicine syndrome score;Fundus photo examination;