Are AGEs, as a predictor of increased risk for cardiometabolic syndrome, increased in shift workers?
Completed
- Conditions
- diabetic cardiovascular complications100126531001842410047066
- Registration Number
- NL-OMON38945
- Lead Sponsor
- Rijksuniversiteit Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
All shift workers (male and female) who have worked on irregular schedules for at least 3 years and that have to work on average for at least 5 nights per month (at least 3 hours between midnight and 6 a.m.), will participate in this study.
Matched by age, non-shift workers will serve as a control group.
Exclusion Criteria
Exclusion criteria for the shift work group is working in irregular shifts for less than 3 years, or less than 5 nights per month. Exclusion criteria for the non-shift workers group is when a person is working in irregular shifts or has been working in night shift work but not anymore at the time of the study. For both groups, people below 18 years of age are excluded.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Average amount of skin AGEs in shift workers and non-shift workers matched by<br /><br>age. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Exploring correlations, in the shift work and the control groups, between the<br /><br>amount of AGEs and factors that are known from the literature to play a role in<br /><br>shift workers: 1) age, 2) number of years working (on shifts), 3) social jetlag<br /><br>(Wittmann et al. 2006; Roenneberg et al. 2012), 4) eating habits (e.g. % fatty<br /><br>food, % sugars and timing), and 5) quality/duration of sleep. A model to assess<br /><br>the individual contribution of each factor on top of the contribution of being<br /><br>shift worker will also be explored. </p><br>