Effect of ageing on interpretation of disease activity measures and on cognition, physical activity and performance in patients with rheumatic disorders.
- Conditions
- musculoskeletal disordersRheumatic diseases1000381610013361
- Registration Number
- NL-OMON52497
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 840
Inclusion criteria, RA population
- Age between 55 - 85 years at baseline.
- Diagnosis of RA by treating rheumatologist.
- Patients > 80 years who are physically unable to complete the whole study
procedure (i.e. geriatric patients who are considered frail by the
rheumatologist and/or patient itself), are allowed to undergo only part of the
study measurements. The rheumatologist who invites a patient > 80 years
explains this option to the patient; the patient is then allowed to choose
which measurement protocol suits him/her best.
Inclusion criteria, control population
- Age between 55 - 85 years at baseline.
- No diagnosis of RA, or other inflammatory RMD (osteoarthritis allowed).
- Controls > 80 years who are physically unable to complete the whole study
procedure (i.e. geriatric controls who are considered frail), are allowed to
undergo only part of the study measurements. The research assistant who
contacts the control after a control indicated his/her interest in the study,
explains this option to the control; the control is then allowed to choose
which measurement protocol suits him/her best.
Exclusiecriteria:
- Have severe comorbidity and the treating rheumatologist or research team
decides they should not be included in the study because of health reasons.
- Do not understand the Dutch language and/or are not able to understand the
study information.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary objective: to investigate how measures of disease activity and measures<br /><br>for cognition, physical activity and performance behave in ageing population<br /><br>controls and RA patients. If an differential effect of age on outcome over time<br /><br>is apparent, the presence of an inclination point will be assessed. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary objective: in case of differences between ageing RA patients and<br /><br>population controls, we will also investigate what additional factors might<br /><br>explain these differences.</p><br>