Comparing the effects of symbiotic therapy with clomiphene in male infertility with idiopathic oligoastenospermia: a randomized clinical trial
- Conditions
- male infertility with idiopathic oligoastenospermia.Male infertility
- Registration Number
- IRCT20190831044653N3
- Lead Sponsor
- Bojnourd University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Male
- Target Recruitment
- 60
sperm concentration in semen <15000000 per cc
Percentage of progressive motile spermatozoa < 32%
Total motility <40%
Total ejaculated spermatozoa<39*106
Normal level of FSH, LH, Prolactin, and free testosterone in serum
Smoking or alcoholic consumption
White blood cells in semen >10 6
Chances of being treated with gonadotropins, anabolic steroids, cancer chemotherapy, NSAIDs
Have been treated with infertility medications since two months ago
Unwillingness to cooperate during treatment
A medical history of chemotherapy or radiotherapy for cancer management
A history of X ray radiation exposure since 8 months ago
Y chromosome microdeletion
Karyotype alterations
Testicular atrophy and lack of testicular descending
Other secondary causes of infertility
History of liver dysfunction and sensitivity to clomiphene
Medical history of infertility therapy since 2 months ago
Ejaculated volume <1.5 ml
Percentage of typical forms<4%
abnormal level of FSH, LH, prolactin and free testosterone in serum
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sperm concentration in semen. Timepoint: end of study. Method of measurement: Sperm count in semen is calculated using sperm concentration. Sperm concentration refers to the number of sperm per unit volume of semen.
- Secondary Outcome Measures
Name Time Method