VITAL - VAP Prevention by BIP (Bactiguard Infection Protection) ETT Evac in Belgian ICUs
- Conditions
- Ventilator-associated Pneumonia
- Interventions
- Device: BIP ETTEvacDevice: ETTEvac
- Registration Number
- NCT04242706
- Lead Sponsor
- Bactiguard AB
- Brief Summary
The study objective is to determine VAP (Ventilator Associated Pneumonia) baseline incidence in the ICU in patients receiving endotracheal tubes with evacuation lumen with and without Bactiguard coating. The study is randomized, prospective, controlled and blinded. All adult patients hospitalized in the ICUs from two tertiary hospitals (i.e.: Centre Hospitalier Universitaire Sart Tilman Liège , Centre Hospitalier Chrétien de Liège) and considered to be ventilated for more than 24 hours will be eligible to participate in the study.
- Detailed Description
The aim of the study is to determine VAP (Ventilator Associated Pneumonia) baseline incidence in the ICU in patients receiving endotracheal tubes with evacuation lumen with and without Bactiguard Infection Protection (BIP) coating.
VAP is likely to occur in 10-20% of patients who are ventilated for at least 48 hours. These patients face a mortality risk estimated to be twice as high compared with similar ICU patients without VAP. Furthermore, VAP results in an average excess length of ICU stay with high hospital cost.
Bactiguard has developed an endotracheal tube coated with a thin layer of non-releasing metals (gold, silver and palladium) firmly attached to the surface. This Bactiguard coating is tissue friendly and aims to achieve an optimal combination of anti-infective properties to reduce biofilm formation, colonization and subsequent respiratory infection. Bactiguard coated urinary products have been on market since 1995 (initially in US, then also in Japan \& Europe) and used in a large number of clinical studies and evaluations, showing reduction of urinary tract infections and also antibiotics use. A BIP ETT (without evacuation lumen) clinical safety and tolerability study was performed at Karolinska University Hospital during 20128. The study showed that BIP ETT is safe, well tolerable and performs well in clinical settings.
The present study of BIP ETT with evacuation lumen is randomized, prospective, controlled and blinded. All adult ICU patients hospitalized in the ICUs from two tertiary hospitals (i.e.: Centre Hospitalier Universitaire Sart Tilman Liège , Centre Hospitalier Chrétien de Liège) and considered to be ventilated for more than 24 hours will be eligible to participate in the study. 300 patients in total will be used to determine baselines levels (150 in each group).
The study tubes will be available not only in the ICUs but also in the emergency department, including the emergency vehicles, and in every hospital wards. The study tubes will not be available in the operating rooms except in the Post Anesthesia Care Units (PACU) and Recovery rooms.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 323
- intubation with a study tube and a presumed duration of ventilation for more than 24h,
- age > 18 y,
- signed informed consent
- tracheostomized patient
- life expectancy less than 48h,
- previous participation in the study
- pregnant women.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental group BIP ETTEvac Endotracheal tube with evacuation lumen with Bactiguard coating. Control group ETTEvac Endotracheal tube with evacuation lumen without Bactiguard coating.
- Primary Outcome Measures
Name Time Method VAP incidence Up to 28 days after inclusion Ventilator Associated Pneumonia incidence
- Secondary Outcome Measures
Name Time Method Antibiotics consumption Up to 28 days after inclusion Duration of ventilation Up to 28 days after inclusion Days of intubation with study tube
VAT incidence Up to 28 days after inclusion Ventilator Associated Tracheabronchitis incidence
Duration of ICU and hospital stay Up to 28 days after inclusion VAC and iVAC Up to 28 days after inclusion Ventilator associated Condition and infectious iVAC
Nosocomial infections Up to 28 days after inclusion Incidence of any kind of nosocomial infection
Mortality Up to 60 days after inclusion Tracheal bacterial colonization Up to 28 days after inclusion Incidence of tracheal bacterial colonization reaching a CFU Count 10\^6 CFU/ml
Trial Locations
- Locations (2)
Centre Hospitalier Universitaire Sart Tilman Liège
🇧🇪Liège, Belgium
Centre Hospitalier Chrétien de Liège and Centre Hospitalier Chrétien (CHC Clinique de l'Espérance)
🇧🇪Liege, Belgium