Does the use of antenatal corticosteroids reduce respiratory morbidity in babies born in late preterm period?

Not Applicable

• Conditions: Respiratory

• Registration Number: PACTR202304579281358
• Lead Sponsor: Shittu khadijah

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-04-05
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 286

Inclusion Criteria

All consenting pregnant women at the General Hospital Ifako Ijaye with gestational age between 34+0 and 36+6 weeks, who were at high risk of delivering before 37 weeks.
A high probability of preterm delivery includes;
Women with intact membranes and at least 3 cm dilation or 75% effacement of the cervix
Spontaneous rupture of the membranes
Expected preterm delivery for any other indication by induction of labour or caesarean section.

Exclusion Criteria

All pregnant women with multiple pregnancy;
Suspected or diagnosed major congenital malformations;
Uncertain gestational age
Clinical evidence of chorioamnionitis;
Previous corticosteroid use during the antenatal period
A woman who is expected to deliver in less than 12 hours.
Women who were discharged from the hospital while still pregnant and who went on to deliver elsewhere were excluded from the study after randomization.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence of neonatal respiratory morbidity. These include: Respiratory distress syndrome; Transient tachypnea of the newborn and the need for ventilatory support within 72 hours of delivery with supplemental oxygen for at least 2 hours. Any neonate who had any of the 3 conditions is said to have had a respiratory morbidity.

Secondary Outcome Measures

Name	Time	Method
These include: type of delivery; gestational age at birth; Apgar Scores at first and fifth minutes; admission to the Special Care Baby Unit (SCBU); neonatal hypoglycemia; neonatal jaundice; neonatal sepsis; other neonatal morbidities; length of stay at the hospital; neonatal death within 72 hours of delivery; the need for resuscitation at birth and feeding difficulties.