The Effect of Antenatal Corticosteroid on Umbilical Artery Doppler Velocimetry in IUGR

Completed

• Conditions: Intrauterine Growth Restriction
• Interventions: Other: ultrasonography

• Registration Number: NCT05588986
• Lead Sponsor: Merve Demir

Brief Summary

The purpose of this study is to evaluate the effect of antenatal corticosteroid administration on umbilical artery Doppler velocimetry measurements in pregnancies complicated by IUGR.

Detailed Description

This study was conducted with pregnant women who were likely to have preterm birth and were treated with antenatal corticosteroids. Betamethasone was used as an antenatal corticosteroid. UA Doppler measurements (PI, S/D ratio, RI) before antenatal corticosteroid administration and 24 and 48 hours after the last dose of corticosteroid administration were evaluated in pregnant groups complicated with IUGR and uncomplicated with IUGR and compared with each other.

Study Timeline

• Study Start: 2018-02-02
• Primary Completion: 2018-09-02
• Study Completion: 2019-02-02
• Study First Submitted: 2022-10-16
• Study First Submitted QC: 2022-10-18
• Study First Posted: 2022-10-20
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-31
• Last Update Posted: 2023-08-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 149

Inclusion Criteria

pregnant women who were likely to have preterm delivery and were treated with antenatal corticosteroids.

Exclusion Criteria

Pregnant women who had complicated pregnancy with fetal anomaly, who had multiple pregnancies, who left their pregnancy follow-up unfinished, and those under 18 years of age were excluded from the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
with IUGR	ultrasonography	Pregnant women who received antenatal corticosteroid therapy and complicated with intrauterine growth retardation
without IUGR	ultrasonography	Pregnant women who received antenatal corticosteroid therapy and were not complicated by intrauterine growth retardation

Primary Outcome Measures

Name	Time	Method
Resistive Index (RI)	2018-2019	Resistive Index (RI) = (Peak systolic velocity - end diastolic velocity)/(peak systolic velocity)
pulsatility index (PI)	2018-2019	Pulsatility Index (PI) = (Peak systolic velocity - end diastolic velocity)/(time averaged maximum velocity)
systolic:diastolic ratio (S/D ratio)	2018-2019	Peak systolic velocity/end diastolic velocity

Trial Locations

Locations (1)

Merve Demir; 🇹🇷 Kocaeli, Turkey