The impact of cytotoxic T lymphocytes on the lifespan of productively infected cells in HIV infectio
Completed
- Conditions
- AIDSHIV1002146010047438
- Registration Number
- NL-OMON39416
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
1. Written informed consent, including permission to store blood samples.
2. 18 years or older.
3. Diagnosis of HIV-1 infection: detectable plasma HIV-1 RNA load and/or serum p24 antigen
4. Infection with subtype B HIV-1
5. No prior antiretroviral treatment
6. Patient is scheduled to start the first HAART
7. A regimen including efavirenz or rilpivirine next to a backbone of two nucleot(s)ide reverse transcriptase inhibitors is to be administered
Exclusion Criteria
1. CD4 count < 100 cells/mm3
2. Immunosuppressive medication
3. For female subjects: pregnancy (positive urine pregnancy test)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primarily we will determine the average lifespan and dynamics of (productively)<br /><br>infected cells in different individuals and correlate this with parameters of<br /><br>the CTL-response (the height, breadth and quality of the T-cell response<br /><br>against HIV-gag epitopes) before HAART and/or the HLA background of the<br /><br>subjects. </p><br>
- Secondary Outcome Measures
Name Time Method <p>NVT</p><br>