effect of amlodipine on oxidative stress markers and serum ferritin level in ß-thalassemia patients

Phase 2

Recruiting

• Conditions: ß-thalassemia.; Beta thalassemia; D56.1

• Registration Number: IRCT20090613002027N16
• Lead Sponsor: Sari University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 October 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

Beta-thalassemia patients with moderate to severe heart sediment (based on MRI T2 less than 15 milliseconds)
Age over 18 years
Written informed consent

Exclusion Criteria

Other medicines for calcium blocker (verapamil-diltiazem-cartidilol)
Continuous hypotension due to heart failure
Aortic valve stenosis
Sinoatrial node diseas
Heart failure

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oxidative stress indices (malondialdehyde, carbonyl protein and total antioxidant). Timepoint: Baseline, month 6 and month 12. Method of measurement: Laboratory analysis.

Secondary Outcome Measures

Name	Time	Method
Ferritin. Timepoint: Baseline, month 6 and month 12. Method of measurement: Laboratory analysis.