Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment

Not Applicable

Recruiting

• Conditions: Lung Cancer; Radiation Therapy Complication
• Interventions: Radiation: Xenon-enhanced Ventilation CT-guided Radiotherapy

• Registration Number: NCT05134558
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Detailed Description

There has been an increase in the application of radiation therapy in the treatment of lung tumors; however, the associated side effect, called radiation pneumonitis, can significantly reduce lung function and the quality of life of patients, eventually leading to fatal consequences. The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy. The investigators' goal is to optimally protect the lung function of the patients and reduce the incidence of radiation pneumonitis.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2020-02-04
• Status Verified: 2021-09
• Study First Submitted: 2021-09-22
• Study First Submitted QC: 2021-11-14
• Last Update Submitted: 2021-11-14
• Study First Posted: 2021-11-26
• Last Update Posted: 2021-11-26
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients aged 20-80 years, with lung cancer receiving thoracic radiotherapy in NTUH, from February 2020 to December 2024.

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Exclusion Criteria

• The age is less than 20 years old or older than 80 years old.
• Unstable clinical condition, unable to maintain apnea for 15 second, and history of prior adverse reaction to xenon.
• Renal insufficiency patients.
• Claustrophobia
• Those who are pregnant.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Xenon-enhanced Ventilation CT-guided Radiotherapy	Xenon-enhanced Ventilation CT-guided Radiotherapy	Patients will be receiving Xenon-enhanced Ventilation CT-guided Radiotherapy for functional lung avoidance. The doses for the tumors, lungs, and organs at risk will be examined and evaluated.

Primary Outcome Measures

Name	Time	Method
Incidence of radiation pneumonia	Within 1 year of radiation therapy	Incidence of radiation pneumonia

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan