Spontaneous versus spontaneous timed mode of assisted ventilation in patients with chest wall disease and stable neuromuscular disease

Recruiting

• Conditions: euromuscular disease; Chest wall disease; Neuromuscular disease; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12608000103369
• Lead Sponsor: Institute for Breathing And Sleep

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2008-02-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Patients with chest wall disease such as kyphoscoliosis or stable neuromuscular disease will be eligible
- Patients have evidence of hypoventilation (defined as day time PaCO2 of > 45 mmHg) at the time of initiation of ventilatory support.
- Patients are already on nocturnal assisted ventilation

Exclusion Criteria

- Patients aged less than 18 years of age
- Patients with Chronic Obstructive Pulmonary Disease (COPD)
- Patients with progressive neuromuscular disease such as motor neurone disease
- Patients with a tracheostomy in situ
- Patients in whom we are unable to obtain informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correction of hypoventilation measured as the difference between evening (pre-ventilation) and morning (post-ventilation) PaCO2, and by trends in transcutaneous CO2 measurement across the whole of sleep, and during raid eye movement (REM) sleep periods.[Assessed after 14 days of ventilation on each mode];Sleep quality as assessed by the number of events overnight [arousals and apnea hypopnea index (AHI)] and sleep efficiency[Assessed after 14 days of ventilation on each mode];Degree of desaturaion as assessed by the total sleep time below 90% and lower. Also the lowest value of desaturation during Non-Rapid Eye Movement sleep (NREM) and Rapid Eye movement sleep (REM).[Assessed after 14 days of ventilation on each mode]

Secondary Outcome Measures

Name	Time	Method
Patient preference for mode of ventilation according to a standardised questionnaire[Assessed after 14 days of ventilation on each mode];Patient?s perception of sleep quality according to a standardised questionnaire[Assessed after 14 days of ventilation on each mode];Under-triggering or over-triggering as assessed from the sleep study[Assessed after 14 days of ventilation on each mode]