High-flow Nasal Cannula Versus Noninvasive Positive Pressure Ventilation Therapy After Early Extubation for Patients With Chronic Obstructive Pulmonary Disease
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- COPD
- Sponsor
- Chinese PLA General Hospital
- Enrollment
- 502
- Locations
- 1
- Primary Endpoint
- reintubation
- Last Updated
- 6 years ago
Overview
Brief Summary
High-flow nasal cannula oxygen therapy(HFNC) has proved no significant difference compared with noninvasive positive pressure ventilation (NPPV) in preventing postextubation respiratory failure and reintubation in patients with acute hypoxemic respiratory failure.However, the efficacy of early postextubation sequential HFNC in COPD patients with hypercapnic respiratory failure is inconclusive.
Detailed Description
The investigators conducted this prospective randomized controlled trial to explore the efficacy, safety of HFNC versus NPPV after early extubation in COPD patients with hypercapnic respiratory failure.The investigators hypothesized that the efficacy of HFNC after early extubation is non-inferior to that of NPPV.
Investigators
Lixin Xie
Director of Department of Respiratory and Critical Care Medicine, Chinese PLA General Hospital
Chinese PLA General Hospital
Eligibility Criteria
Inclusion Criteria
- •COPD patients with bronchopulmonary infection
- •Patients with hypercapnia respiratory failure treated with invasive mechanical 3.14 days ≥ invasive mechanical ventilation ≥ 48 hours; 4.Reached the pulmonary infection control (PIC) window; 5.Have self-care ability with oxygen supply during stable phrase
Exclusion Criteria
- •Severe organ dysfunction;Myopathy or myasthenia gravis;Upper airway obstruction;A large amount of secretions and inability to drain;
Outcomes
Primary Outcomes
reintubation
Time Frame: within the 7 days after extubation.
The primary outcome is reintubation within the 7 days after extubation.
Secondary Outcomes
- Weaning failure(within the7 days after extubation)