Randomised study with ciprofloxacine in acute pancreatitis

Completed

• Conditions: Acute pancreatitis; Digestive System

• Registration Number: ISRCTN75232398
• Lead Sponsor: Hospital Universitari De Bellvitge (Spain)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2008-04-16
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

All adult patients of either sex:
1. Without previous antibiotic treatment
2. With detectable pancreatic necrosis in a contrast-enhanced computed tomography (CT) scan 25 performed within 48 - 72 hours of admission

Exclusion Criteria

1. Antibiotic allergy
2. Clinical evidence of sepsis on admission

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine whether prophylaxis with intravenous ciprofloxacin could reduce the incidence of infected pancreatic necrosis.

Secondary Outcome Measures

Name	Time	Method
Effects on: <br>1. Mortality rate<br>2. Extra-pancreatic infections<br>3. Surgical treatment, its timing and the re-operation rate<br>4. Development of organ failure 2 <br>5. In-hospital as well as intensive care unit (ICU) length of stay