Evaluation of the efficacy and safety of ciprofol in the induction and maintenance period of anesthesia in elderly vulnerable patients: a randomized, controlled clinical trial
- Conditions
- Post-induction hypotension
- Registration Number
- ChiCTR2400088936
- Lead Sponsor
- The Traditional Chinese Medicine Hospital of Kunshan
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
(1) Age= 60 years old<br>(2) Use a non-invasive continuous arterial blood pressure monitoring system and (3) elective non-cardiac surgery planned under general anesthesia<br>(4) ASA Grading I.~IV.<br>(4) Modified vulnerability index MFI=3<br>(5) Postoperative planned extubation<br>(6) Informed consent, voluntarily participate in the trial, and sign the informed consent form
(1) Use regional anesthesia <br>(2) Severe liver disease<br>(3) Chronic kidney disease requiring dialysis<br>(4) Gastroesophageal reflux disease<br>(5) Obstructive sleep apnea<br>(6) History of drug dependence<br>(7) Neurological diseases<br>(8) Systolic blood pressure = 180mmHg and/or diastolic blood pressure = 100mmHg at screening<br>(9) Systolic blood pressure < 90mmHg at screening<br>(10) Subjects who are considered inappropriate by the investigator to participate in this study.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bispectral Idex during the period from skin incision to the last skin suture;
- Secondary Outcome Measures
Name Time Method rate of hypotension after induction;Delirium Screening Scale;Time to loss of eyelid reflex;Time to loss of consciousness after anesthesia induction;Time to tracheal extubation;Time to recovery of consciousness from tracheal extubation;Cardiac output;Stroke variability;Peripheral vascular resistance;Oxygen supply index;Oxygen consumption index;Postoperative delirium-associated serum biomarkers;Modified Aldrete score;Brice questionnaire;rate of adverse events;